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Vitamin U

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Vitamin U is a tentative designation given by Garnett Cheney for antipeptic ulcer factors in cabbage juice that he found to cure peptic ulcers in eleven days versus thirty-seven days for placebo.[1] Other research points to fibre preventing ulcers.[2] Iso-thio-cyanates are an important factor in the action of Brassicaceae against Helicobacter Pylori,[3] and ITC is not a molecule, but a functional group on many different molecules, Sinigrin being a notable precursor of allyl-ITC. Other research has found results with indole-nucleated molecules, Glucobrassicin being one from which is formed two others: indole-3-carbinol and diindolylmethane. Glucosinolate is another group of molecules in the Brassicaceae family with gastro- and hepato-protective action.[4]

Hepatology

While Brassicaceae is a large genus of plants containing hepato-protective agents[5], it does not contain a monopoly on them.

Oncology

I3C promotes apoptosis in cancer cells with many molecular targets.[6] Broccoli sprouts are rich enough in glucosinolates for experimental results against aflatoxin.[7]

Contraindications

Brassica species probably cause baby colic in breast-feeding.[8]

References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18104715, please use {{cite journal}} with |pmid=18104715 instead.[unreliable medical source?]
  2. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20166992, please use {{cite journal}} with |pmid=20166992 instead.
  3. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15246236, please use {{cite journal}} with |pmid=15246236 instead.[unreliable medical source?]
  4. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11506821, please use {{cite journal}} with |pmid=11506821 instead.
  5. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20128046, please use {{cite journal}} with |pmid=20128046 instead.
  6. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16082211, please use {{cite journal}} with |pmid=16082211 instead.
  7. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16284385, please use {{cite journal}} with |pmid=16284385 instead.
  8. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8537569, please use {{cite journal}} with |pmid=8537569 instead.[unreliable medical source?]

Further reading

  • Lee, Na Young; Park, Kui Young; Min, Hye Jung; Song, Kye Yong; Lim, Yun Young; Park, Juhee; Kim, Beom Joon; Kim, Myeung Nam (2012). "Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines". Annals of Dermatology. 24 (1): 39–44. doi:10.5021/ad.2012.24.1.39. PMC 3283849. PMID 22363154.
  • Jiang, Xiao-Lin; Lim, Lee Wah; Takeuchi, Toyohide (2011). "Vitamin U-bonded Stationary Phase in Capillary Ion Chromatography". Analytical Sciences. 27 (12): 1203–6. doi:10.2116/analsci.27.1203. PMID 22156247.
  • Kim, Won-Serk; Yang, You Jin; Min, Hyung Geun; Song, Min Gyu; Lee, Ji-Seon; Park, Keung-Young; Kim, Jin-Ju; Sung, Jong-Hyuk; Choi, Jun-Seok (2010). "Accelerated Wound Healing by S-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway". Pharmacology. 85 (2): 68–76. doi:10.1159/000276495. PMID 20110751.
  • Ichikawa, Takafumi; Ito, Yuko; Saegusa, Yoichi; Iwai, Tomohisa; Goso, Yukinobu; Ikezawa, Tomoaki; Ishihara, Kazuhiko (2009). "Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa". Journal of Gastroenterology and Hepatology. 24 (3): 488–92. doi:10.1111/j.1440-1746.2008.05667.x. PMID 19175830.
  • Kopinski, JS; Fogarty, R; McVeigh, J (2007). "Effect of s-methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs". Australian Veterinary Journal. 85 (9): 362–7. doi:10.1111/j.1751-0813.2007.00197.x. PMID 17760939.
  • Shaw, Ashley Lynn (2007). The efficacy of DL-Methionine methylsulfonium chloride on performance characteristics and intestinal tract integrity in broilers (MS Thesis). Auburn University. OCLC 191697478.
  • Elbers, A.; Vos, J.; Hemke, G.; Hunneman, W. (1995). "Effect of hammer mill screen size and addition of fibre or S-methylmethionine-sulphonium chloride to the diet on the occurrence of oesophagogastric lesions in fattening pigs". Veterinary Record. 137 (12): 290–3. doi:10.1136/vr.137.12.290. PMID 8533223.
  • Salim, AS (1993). "Sulfhydryl-containing agents in the treatment of gastric bleeding induced by nonsteroidal anti-inflammatory drugs". Canadian journal of surgery. Journal canadien de chirurgie. 36 (1): 53–8. PMID 8443719.
  • Salim, AS (1992). "Role of sulphydryl-containing agents in the management of recurrent attacks of ulcerative colitis. A new approach". Pharmacology. 45 (6): 307–18. doi:10.1159/000139016. PMID 1362613.
  • Salim, AS (1992). "Sulphydryl-containing agents stimulate the healing of duodenal ulceration in man". Pharmacology. 45 (3): 170–80. doi:10.1159/000138995. PMID 1438525.
  • Tamás, J; Hegedüs, M; Bokori, J (1986). "Oesophagogastric ulcer in swine and vitamin U. IV. Efficiency of the Hungarian vitamin U preparation in reduction of economic losses". Acta veterinaria Hungarica. 34 (1–2): 93–100. PMID 2953196.
  • Cheney, Garnett; Waxler, Samuel H.; Miller, Ivan J. (1956). "Vitamin U Therapy of Peptic Ulcer: Experience at San Quentin Prison". California Medicine. 84 (1): 39–42. PMC 1532869. PMID 13276831.
  • Cheney, Garnett (1952). "Vitamin U therapy of peptic ulcer". California medicine. 77 (4): 248–52. PMC 1521464. PMID 13009468.
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