Tet methylcytosine dioxygenase 1
Template:PBB Tet methylcytosine dioxygenase 1 is a enzyme that in humans is encoded by the TET1 gene.[1]
Tet1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC).[2] Tet1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner.[3] The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals.[3]
References
- ^ "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26T20:28:02.557056-08:00.
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Further Reading
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