Basket cell
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| Basket cell | |
|---|---|
| Details | |
| Location | Cerebellum |
| Shape | multipolar |
| Function | Inhibitory interneuron |
| Presynaptic connections | Parallel fibers |
| Postsynaptic connections | Purkinje cells |
| Identifiers | |
| NeuroLex ID | nifext_160 |
| Anatomical terms of neuroanatomy | |
Basket cells are inhibitory GABAergic interneurons found in several brain regions: the molecular layer of the cerebellum, the hippocampus, and the cortex.[1]
Cerebellum
In the cerebellum, they synapse on the cell bodies of Purkinje cells, and are multipolar and stellate, with freely branching dendrites, which are dilated and knotty.
Hippocampus
Hippocampal basket cells target somata and proximal dendrites of pyramidal neurons. Like their counterparts in the cortex,[2]hippocampal basket cells are also parvalbumin-expressing and fast-spiking. In the CA3 region of the hippocampus, basket cells can often form recurrent inhibition loops with pyramidal cells. [3] Projections from a pyramidal cell will innervate the basket cell, which in turn has a projection back onto the original pyramidal cells. Since basket cells are inhibitory, this generates a closed loop that can help dampen excitatory responses.
Cortex
In the cortex, basket cells have sparsely branched axons giving off small pericellular, basket-shaped elaborations at several intervals along their length. There are three types of basket cells in the cortex, the small, large and nest type:[4] The axon of a small basket cell arborizes in the vicinity of that same cell's dendritic range. In contrast, large basket cells innervate somata in different cortical columns. The nest basket cells are an intermediate form of the small and large cells, their axons are confined mainly to the same cortical layer as their somata.
Additional images
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Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-). Basket cell labeled BC. -
Cerebellum.
External links
- Cell Centered Database - Cerebellar basket cell
- Template:EMedicineDictionary
- NIF Search - Basket Cell via the Neuroscience Information Framework
References
- ^ Jones, Edward (1984). Cerebral Cortex: Volume 1: Cellular Components of the Cerebral Cortex. Springer. ISBN 9780306415449.
- ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.neunet.2004.04.003, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1016/j.neunet.2004.04.003instead. - ^ Bryne, John. "Feedback/recurrent inhibition: Feedback inhibition in microcircuits". Neuroscience Online. University of Texas Health Center.
- ^ Fox, K. "Barrel Cortex", Cambridge University Press, pp. 55-56
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