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This is an old revision of this page, as edited by 213.83.135.20 (talk) at 11:26, 24 February 2016 (→Cleanup). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:Wikiproject MCB

Cleanup

Someone has greatly expanded the article, but it is now almost exclusively about allergy. Scientific articles in this field should really follow the form (1) Physiology (normal function), (2) Genetics/molecular biology (ultrastructure and DNA), (3) Role in disease (allergy, in this case), (4) Therapeutic role (e.g. cromoglycate or omalizumab).

In its present form, the article is off-balance. Could the new contributor kindly do some tidying up and avoid speculation as much as possible? JFW | T@lk 21:26, 8 October 2005 (UTC)[reply]

I've tried to reword it so the article is more centred on IgE rather than drifting into slightly irrelevent stuff. Obviously IgE and allergy are intimately connected topics, but hopefully this is an acceptable improvement?

[LKP:] Someone got the history of the discovery of IgE wrong, the author seemingly confused Norman's and Lichtenstein's work on AgE (antigen E from ragweed, an allergen component) with IgE, the immunoglobulin identified during the same period: I posted this correction which was removed after 4 minutes. Please read the suggested literature ( Allergol Int. 2013 Mar;62(1):3-12. doi: 10.2332/allergolint.13-RAI-0537.Mast cells and IgE: from history to today. Saito H1, Ishizaka T, Ishizaka K. ) and the original references and the mistake should be clear to all:

IgE was simultaneously discovered in 1966-7 by two groups: Dr.s Kimishige and Teruko Ishizaka and Dr. Margaret M. Hornbrook[1] in the Children's Asthma Research Institute and Hospital in Denver, CO. and by Gunnar Johansson and Hans Bennich in Uppsala, Sweden [2]


AIT


The article continues to contain highly biased and incomplete information. Unfortunately I have only the knowledge to recognize this, and do not feel I have the knowledge to correct it. I suggest the reader take this article with a grain of salt and consider alternate sources such as MedLine.

LNB


The "Allergy Misconceptions" segment is highly subjective and suspicious of personal agenda. It should be designated as such by a moderator or, preferably, removed completely as it has nothing to do with IgE.

GPG, NREMT-P

^ Yes I just removed it a few minute ago. People are confusing mild immune responses to foods (IgG or not) with truly allergic life-threatening illness mediated by IgE. Anonywiki 23:20, 5 August 2007 (UTC)[reply]

Request for rewriting run-on sentence

     Can someone, not necessarily an expert, please rewrite this run on sentence;

"IgE that can specifically recognise an "allergen" (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis." Thanks very much 220.101.92.34 (talk). —Preceding undated comment added 07:50, 11 May 2011 (UTC).[reply]

What's the normal adult and/or children's level of IgE?

i added a citation needed label to the value that's already in the article.

i spent a long time googling and haven't found any quotes of "normal" levels (neither with nor without a description of how many standard deviations "normal" actually means!).

If somebody can find this, then we could add one or both of the following refs and also give the value in IU/mL (or kIU/L, which is the same thing). The conversion according to these two references is: 1 IU/mL = 1kIU/L = 2.44 ng/mL. The polish reference gives 2.44, the US one 2.4, so presumably the polish one just goes to higher precision and the US one is a rougher approximation.

These would put 75 ng/mL = 30.7 kIU/L or 31 kIU/L to keep about the same level of precision.

However, until we get a reference, i don't see much point in adding the kIU/L value.

Boud (talk) 19:32, 7 August 2008 (UTC)[reply]

Irrelevant/unexplained?

This hardly seems relevant - when its there with out further introduction?

"In 1975, Robert N. Hamburger, M.D. published "Peptide Inhibition of the P-K Reaction" based on blocking up to 89% of the IgE receptors on mast cells by the pentapeptide representing amino acids 320 to 324 on the epsilon chain of IgE.[13] Confirming the IgE binding site, in 1979 he published in Immunology "Inhibition of IgE binding to tissue culture cells and leucocytes by pentapeptide" (ref).

I'll remove unless someone objects? — Preceding unsigned comment added by Radicularia (talk • contribs) 21:25, 4 March 2012 (UTC)[reply]

Needs to be comprehensible to the intelligent layman

This article is full of technical terms, explained only by links to other pages, which themselves are full of other technical terms. This page may (?) be well written for biologists and doctors. Someone please make it accessible by the average parent who is looking up information for their hyperallergic children. I do *NOT* mean to "dum it down". Make it as comprehensive as possible. Just leave some of it within reach of non-experts. 69.247.14.176 17:17, 5 February 2015 (UTC)[reply]

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  1. ^ Ishizaka K, Ishizaka T, Hornbrook MM (1966). "Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity". J. Immunol. 97 (1): 75–85. PMID 4162440.
  2. ^ Johansson SG, Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 1967; 13:381-94.
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