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Fasoracetam

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Fasoracetam
Names
IUPAC name
(5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
  • InChI=1S/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1 checkY
    Key: GOWRRBABHQUJMX-MRVPVSSYSA-N checkY
  • InChI=1/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1
    Key: GOWRRBABHQUJMX-MRVPVSSYBL
  • C1CCN(CC1)C(=O)C2CCC(=O)N2
  • O=C(N1CCCCC1)[C@@H]2NC(=O)CC2
Properties
C10H16N2O2
Molar mass 196.246 g/mol
Pharmacology
Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Fasoracetam (NS-105, 5-oxo-D-prolinepiperidinamide monohydrate) is a research chemical studied for its potential as a nootropic class drug of the racetam family.[1]


Effects

Fasoracetam appears to act as a GABAB receptor antagonist. It has been shown to block memory disruptions caused by Baclofen, a GABA B agonist.[2] Fasoracetam upregulates GABA B receptors after repeat dosing.[3]

Fasoracetam may act as a mGluR agonist and research into the efficacy for treating ADHD and cognitive impairment is currently being conducted.[4] [5]

Similar to Coluracetam, Fasoracetam enhances high affinity choline reuptake (HACU). [2]

References

  1. ^ "5-oxo-D-prolinepiperidinamide monohydrate - Compound Summary". Retrieved 21 July 2013.
  2. ^ a b "Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer".
  3. ^ "Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment".
  4. ^ "A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture".
  5. ^ http://www.research.chop.edu/forms/btob/Oct12BtoB.pdf


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