Roger Gosden
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Roger Gordon Gosden | |
|---|---|
 | |
| Born | 23 September 1948 |
| Citizenship | American, British |
| Alma mater | University of Bristol University of Cambridge University of Edinburgh |
| Spouse | Lucinda Veeck Gosden |
| Scientific career | |
| Fields | Physiology Reproductive medicine |
| Institutions | University of Cambridge Duke University Edinburgh Medical School Leeds School of Medicine McGill University Health Centre Eastern Virginia Medical School Weill Cornell Medicine College of William & Mary |
| Theses | |
| Doctoral advisor | Robert Edwards |
Roger Gordon Gosden (born 23 September 1948) is a retired British-American physiologist and pioneer in reproductive medicine, particularly in fertility preservation. He is a researcher who has been involved in the field of human and animal fertility for over three decades. Two out of the many contributions he has made to the understanding of infertility include: defining the loss of ovarian follicles and its implications in forecasting menopause, and pioneering methods of ovarian tissue cryopreservation and transplantation to reverse infertility which has led to 86 live-births as Dec 2016.
Early life and education
Gosden was born on 23 September 1948 in Ryde on the Isle of Wight.[1] He is the son of Gordon Gosden and Peggy Gosden (née Butcher).[2] He attended Chislehurst and Sidcup Grammar School then located in Crittall's Corner in Foots Cray, London Borough of Bexley.[3] He then attended University of Bristol, graduating with a Bachelor of Science degree in 1970.[1] He then attended Darwin College at the University of Cambridge.[4] where he began his research career under the Nobel laureate scientist Robert Edwards.[5][6] He completed his dissertation on Reproductive senescence in female rodents and received his PhD in May 1974.[7]
Research career
Gosden has been a professor of physiology and reproductive sciences for over 33 years from 1976 till 2010, and a researcher in the field since 1970.[citation needed] He began his researcher career working with Robert G. Edwards—one of the first developers of in vitro fertilization (IVF)—at University of Cambridge.[8][6] Gosden went on to become a lecturer in physiology at the University of Edinburgh Medical School from 1976 to 1994,[2] a professor of reproductive sciences at Leeds School of Medicine from 1994 to 1999,[1] the scientific director of reproductive biology at McGill University Health Centre from 1999 to 2001.[3][9]
For the majority of his career, Gosden's scientific interest has been the understanding, forecasting and prevention of infertility.[10] His interest in reproductive senescence–which was expressed in his PhD thesis–continued in his DSc thesis and culminated in a study of the corrolation between the depletion of ovarian follicles and the onset of menopause in 1992.[11] Although the model promoted by Gosden and M? Faddy eventually proved to be not entirely complete, it spurred interest in the use of mathematical analysis to forecast the onset of menopause and infertility.[12]
In the late 1990s, Gosden was also involved in research on the use of ovarian tissue transplantation to reverse infertility, not only due to menopause but also due to cancer treatment or other causes.[13] In 1994, Gosden et al. announced that they had successfully restored fertility to and achieved two live births in sheep through ovarian tissue autotransplantation, one of which had actually been frozen then thawed.[14][15] In collaboration with Sherman Silber, this technique was later extended to women using tissue or the entire ovary transplanted from an identical twin[16] Recently, tissue from pubescent and pre-pubescent children that was frozen before they underwent medical treatment was used to reverse the infertility caused by said treatment.[17] As of December 2016[update], there have been 86 live-births and 9 on-going pregnancies directly as a result of these types of ovarian tissue transplantation.[18]
In 2001, Gosden became the director of scientific research at what was the United State's first IVF center—the Jones Institute for Reproductive Medicine, founded in 1978 at Eastern Virginia Medical School,[1] where he was named the Howard & Georgeanna Professor of Reproductive Medicine.[3] He went on to become the research director of reproductive biology at Weill Cornell Medicine from 2004 till his retirement from the field in 2010.[citation needed]
Personal life and other interests
Gosden married Carole Ann Walsh in 1971 and they had two sons before their divorce in 2003.[1][3] He met Lucinda Veeck while he was working at the Jones Institute in Norfolk where she was previously the director of embryology.[19] She was part of the team that successfully enabled the first American conception and birth through in vitro fertilization.[20][21] They were married in 2004 and he relocated to New York to work at Weill Cornell Medicine where she was an associate professor and director of clinical embryology.[citation needed] They are now both retired and live in Williamsburg, Virginia, where they own and operate an independent publishing company: Jamestowne Bookworks.[19]
Gosden served as a scientific advisor to Celmatix, Inc., which was founded by a his former student.[22][23] He is also a published author who has written several books and editor of three books about other pioneers of medicine and reproductive biology.[19]
Honours, awards and lectures
- Amoroso Lecture (2000) - Society for Reproduction and Fertility[24]
- President’s Lecture (2000) - Society for the Study of Reproduction
- Lilly Lecture (2001) - Royal College of Physicians of Edinburgh
- Distinguished Scientist Lecture (2001) - American Society for Reproductive Medicine[3]
- The Patrick Steptoe Memorial Lecture (2003) - British Fertility Society, Aberdeen[3][25]
- Szulman Lecturer (2006) - University of Pittsburgh
- The Ann McLaren Memorial Lecturer (2011) - British Fertility Society, Dublin
- Honorary Fellow (2011) - British Fertility Society[25]
- Festschrift to honour Roger Gosden (2011) - XVth Development and Function of Reproductive Organs International Conference[26][10]
- Honorary Lifetime Board Member - International Society for Fertility Preservation[27]
- The Howard & Georgeanna Jones Visiting Lecturer (2013) - Johns Hopkins University Medical School
Bibliography
Books
- Gosden, Roger (1985). Biology of menopause: the causes and consequences of ovarian ageing. Academic Press. ISBN 9780122918506.
- Gosden, Roger; Aubard, Yves (1996). Transplantation of Ovarian and Testicular Tissues. Chapman & Hall. ISBN 9780412105319.
- Gosden, Roger (1999). Cheating Time. W. H. Freeman. ISBN 9780716736486.
- Gosden, Roger (2000). Designing Babies: The Brave New World of Reproductive Technology. W.H. Freeman. ISBN 9780716741688.
- Gosden, Roger; Tan, S. L. (2002). The Cryobiology of Assisted Reproduction: Gametes and Gonads. Thieme. ISSN 1526-8004.
{{cite book}}:|work=ignored (help) - Gosden, Roger; Trounson, Alan (2003). Biology and Pathology of the Oocyte: Its Role in Fertility and Reproductive Medicine. Cambridge University Press. ISBN 9780521799584.
- Gosden, Roger; Tulandi, Togas (2004). Preservation of Fertility. Taylor & Francis. ISBN 9781842142424.
- Gosden, Roger; Trounson, Alan; Eichenlaub-Ritter, Ursula (2013). Biology and Pathology of the Oocyte: Role in Fertility, Medicine and Nuclear Reprograming. Cambridge University Press. ISBN 9781107021907.
- Gosden, Roger (2013). A Surgeon's Story: The Autobiography of Robert T. Morris. Jamestowne Bookworks. ISBN 9780989719902.
- Jones Jr., Howard (2014). Gosden, Roger (ed.). In Vitro Fertilization Comes to America: Memoir of a Medical Breakthrough. Jamestowne Bookworks. ISBN 9780989719933.
- Jones Jr, Howard (2015). Gosden, Roger; Gosden, Lucinda Veeck (eds.). Howard and Georgeanna: Sixty Years of Marriage and Medicine. Jamestowne Bookworks. ISBN 9780989719988.
Selected journals
- Gosden, R.G. (1 November 1973). "Chromosomal Anomalies of Preimplantation Mouse Embryos in Relation to Maternal Age" (PDF). Journal of Reproduction and Fertility. 35 (2): 351–354. doi:10.1530/jrf.0.0350351. ISSN 1470-1626. PMID 4796185.
{{cite journal}}: Invalid|ref=harv(help) - Gosden, R.G. (21 May 1974). Reproductive senescence in female rodents (Thesis). University of Cambridge Department of Physiology.
{{cite thesis}}: Invalid|ref=harv(help) - Gosden, R.G. (1988). Experimental and cytological studies of mammalian fertility and infertility with particular reference to the ageing ovary (Thesis). University of Edinburgh Medical School.
{{cite thesis}}: Invalid|ref=harv(help) - Gosden, R.G. (1 February 1990). "Restitution of fertility in sterilized mice by transferring primordial ovarian follicles". Human Reproduction (Oxford, England). 5 (2): 117–122. ISSN 0268-1161. PMID 2324253.
- Faddy, M.J.; Gosden, R.G.; Gougeon, A.; Richardson, S.J.; J.F., Nelson (1 November 1992). "Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause". Human Reproduction. 7 (10). doi:10.1093/oxfordjournals.humrep.a137570. ISSN 0268-1161.
{{cite journal}}: Invalid|ref=harv(help); Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Spears, N.; Gosden, R.G.; Boland, N.I.; Murray, A.A. (1 March 1994). "Mouse oocytes derived from in vitro grown primary ovarian follicles are fertile". Human Reproduction (Oxford, England). 9 (3): 527–532. ISSN 0268-1161. PMID 8006146.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Gosden, R.G.; Baird, D.T.; Wade, J.C.; Webb, R. (1 April 1994). "Restoration of fertility to oophorectomized sheep by ovarian autografts stored at -196 degrees C". Human Reproduction (Oxford, England). 9 (4): 597–603. ISSN 0268-1161. PMID 8046009.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Faddy, M.J.; Gosden, R.G. (1 July 1996). "A model conforming the decline in follicle numbers to the age of menopause in women". Human Reproduction (Oxford, England). 11 (7): 1484–1486. ISSN 0268-1161. PMID 8671489.
- Newton, H.; Gosden, R.G.; Aubard, Y.; Rutherford, A.; Sharma, V. (1 July 1996). "Low temperature storage and grafting of human ovarian tissue". Human Reproduction (Oxford, England). 11 (7): 1487–1491. ISSN 0268-1161. PMID 8671490.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Radford, J.A.; Gosden, R.G; Lieberman, B.A.; Brison, D.R.; Smith, A.R.; Critchlow, J.D.; Russell, S.A.; Watson, A.J.; Clayton, J.A. (14 April 2001). "Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin's lymphoma". Lancet (London, England). 357 (9263): 1172–1175. ISSN 0140-6736. PMID 11323045.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Wang, X.; Gosden, R.G.; Chen, Huifang; Yin, Hang; Kim, S. Samuel; Lin Tan, Seang (24 January 2002). "Fertility after intact ovary transplantation". Nature. 415 (6870): 385. doi:10.1038/415385a. ISSN 0028-0836. PMID 11807540.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Silber, S.J.; Gosden, R.G.; Lenahan, Kathleen M.; Levine, David J.; Pineda, Jorge A.; Gorman, Kim S.; Friez, Michael J.; Crawford, Eric C. (7 July 2005). "Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure". New England Journal of Medicine. 353 (1): 58–63. doi:10.1056/NEJMoa043157. ISSN 0028-4793. PMID 15941849.
{{cite journal}}: Invalid|ref=harv(help); Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - Silber, S.J.; Gosden, R.G.; Grudzinskas, Gedis (11 December 2008). "Successful pregnancy after microsurgical transplantation of an intact ovary". The New England Journal of Medicine. 359 (24): 2617–2618. doi:10.1056/NEJMc0804321. ISSN 1533-4406. PMID 19073987.
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References
- ^ a b c d e Peacock, Scot (2004). Contemporary Authors, New Revision Series. Detroit, Michigan: Gale. ISBN 9780787692018. OCLC 527378529. Retrieved 6 February 2017 – via Encyclopedia.com.
- ^ a b Lumley, Elizabeth (2002). The Canadian Who's Who. University of Toronto Press. p. 514.
- ^ a b c d e f Sleeman, Elizabeth; Neale, Alison; Robinson, Kate, eds. (2003). The International Who's Who 2004. London: Europa Publications Limited. ISBN 9781857432176. OCLC 491652781.
- ^ Prentice, Andrew; Smith, Sophia; et al., eds. (2007). "New York alumni gathering". The Darwinian. Retrieved 6 February 2017 – via Issuu.com.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "About Dr. Roger Gosden". VIVO. Retrieved 6 February 2017.
- ^ a b Gosden (1973), p. 354
- ^ Gosden (1974)
- ^ "World's first test-tube baby Louise Brown has a child of her own". The Independent. 14 January 2007. Retrieved 11 February 2017.
- ^ Dobson, Roger (26 September 1999). "Focus: The Brain Drain: Medical stars pack their bags". The Independent. Retrieved 11 February 2017.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ a b Hillier, P. S. G. (1 February 2012). "Modern methods of fertility preservation: a tribute to Roger Gosden". Molecular Human Reproduction. 18 (2): 57–58. doi:10.1093/molehr/gas003. ISSN 1360-9947.
- ^ References for ovarian depletion research:
- ^ References for interest in ovarian reserve models
- Ranieri, D.M. (1 June 2000). "Ovarian reserve: A simple mathematical problem?". Human Reproduction. 15 (6): 1423–1424. doi:10.1093/humrep/15.6.1423. ISSN 0268-1161.
- Wallace, W. H. B.; Kelsey, T. W. (27 January 2010). "Human Ovarian Reserve from Conception to the Menopause". PLOS ONE. 5 (1): e8772. doi:10.1371/journal.pone.0008772. ISSN 1932-6203. PMC 2811725. PMID 20111701.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Wilkosz, P.; Greggains, G.D.; Tanbo, T.G.; Fedorcsak, P. (13 October 2014). "Female Reproductive Decline Is Determined by Remaining Ovarian Reserve and Age". PLOS ONE. 9 (10): e108343. doi:10.1371/journal.pone.0108343. ISSN 1932-6203. PMC 4195570. PMID 25310678.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help)CS1 maint: unflagged free DOI (link) - Hillier, P. S. G. (1 February 2012). "Modern methods of fertility preservation: a tribute to Roger Gosden". Molecular Human Reproduction. 18 (2): 57–58. doi:10.1093/molehr/gas003. ISSN 1360-9947.
- Kelsey, T. W.; Anderson, R. A.; Wright, P.; Nelson, S. M.; Wallace, W. H. B. (1 February 2012). "Data-driven assessment of the human ovarian reserve". Molecular Human Reproduction. 18 (2): 79–87. doi:10.1093/molehr/gar059. ISSN 1360-9947.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help)
- ^ Oktay, K. (1 November 2001). "Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients". Human Reproduction Update. 7 (6): 526–534. doi:10.1093/humupd/7.6.526. ISSN 1355-4786.
- ^ Prasath, Ethiraj B. (1 January 2008). "Ovarian tissue cryopreservation: An update". Journal of Human Reproductive Sciences. 1 (2): 50–55. ISSN 0974-1208. PMC 2700672. PMID 19562046.
- ^ Prasath, Ethiraj B. (1 January 2008). "Ovarian tissue cryopreservation: An update". Journal of Human Reproductive Sciences. 1 (2): 50–55. ISSN 0974-1208. PMC 2700672. PMID 19562046.
- ^ References for transplantation between twins:
- Silber, S. J. (1 February 2012). "Ovary cryopreservation and transplantation for fertility preservation". Molecular Human Reproduction. 18 (2): 59–67. doi:10.1093/molehr/gar082. ISSN 1360-9947.
- Silber et al. (2005)
- Silber, Gosden & Grudzinskas (2008)
- Lambert, Victoria (26 November 2009). "Fertility: stop all the clocks". Telegraph.co.uk. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
{{cite news}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - Cooperman, Jeannette (7 September 2012). "Dr. Sherman Silber Takes His Reproductive Technology to China". St. Louis Magazine. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
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- ^ References for ovarian cryopreservation and transplantation in children:
- Kelland, Kate (9 June 2015). "Woman gives birth after childhood ovarian tissue transplant". Reuters. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
{{cite news}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - Donnelly, Laura (14 December 2016). "Woman gives birth to baby using ovary frozen in her childhood in 'world first'". The Telegraph. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
{{cite news}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help); no-break space character in|title=at position 65 (help) - W., Christian (17 January 2017). "The Copenhagen Post - Danish News in English". CPH News Online. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
{{cite news}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - Ernst, E.; Kjærsgaard, M.; Birkebæk, N. H.; Clausen, N.; Andersen, C. Y. "Case report: Stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue". European Journal of Cancer. 49 (4): 911–914. doi:10.1016/j.ejca.2012.09.028.
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- Kelland, Kate (9 June 2015). "Woman gives birth after childhood ovarian tissue transplant". Reuters. Archived from the original on 11 February 2017. Retrieved 11 February 2017.
- ^ Jensen, A. K.; Macklon, K. T.; Fedder, J.; Ernst, E.; Humaidan, P.; Andersen, C. Y. (27 December 2016). "86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children". Journal of Assisted Reproduction and Genetics. doi:10.1007/s10815-016-0843-9. ISSN 1573-7330. PMID 28028773.
- ^ a b c Gosden, Roger; Gosden, Lucinda Veeck (1 December 2012). "About Us". Jamestowne Bookworks. Retrieved 10 February 2017.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ Mundy, Liza (24 April 2007). Everything Conceivable. Knopf Doubleday Publishing Group. ISBN 9780307267276.
- ^ Garcia, Jairo; Veeck, Lucinda; Acosta, Anibal; Andrews, Mason C.; Jones, Georgeanna Seegar; Jones, Howard W.; Mantzavinos, Themis; Mayer, Jacob; McDowell, Jeanne. "In vitro fertilization in Norfolk, Virginia, 1980–1983". Journal of in Vitro Fertilization and Embryo Transfer. 1 (1): 24–28. doi:10.1007/BF01129616. ISSN 0740-7769.
{{cite journal}}: Unknown parameter|displayauthors=ignored (|display-authors=suggested) (help) - ^ Mollory, Chris; Charlie, Grebenstein; et al. (2016). "Digital Healthcare - RSA Talent Equity Report". RSA Group: 23. Retrieved 8 February 2017.
- ^ "Celmatix, Inc. - Relationship Science". Relationshipscience.com. Archived from the original on 8 February 2017. Retrieved 8 February 2017.
{{cite web}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - ^ "Past Awards - Society for Reproduction and Fertility". Society for Reproduction and Fertility. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
{{cite news}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - ^ a b Campbell, Trudi (ed.). "Newsletter - Autumn 2013" (PDF). British Fertility Society. Bioscientifica Ltd. pp. 5, 7. ISSN 2045-6891.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "XVth Development and Function of Reproductive Organs International Conference". University of St Andrews. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
{{cite web}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - ^ Bronchart, Rudy Lechantre and Gregory. "Board Of Directors". International Society for Fertility Preservation. Archived from the original on 6 February 2017. Retrieved 6 February 2017.
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External links
Category:People educated at Chislehurst and Sidcup Grammar School Category:People from the Isle of Wight Category:1948 births Category:People from Ryde
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