Clark L. Anderson
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Clark Lawrence Anderson, a physician and immunologist, is Professor Emeritus in the Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States. His academic career has focused on the biological effects of Immunoglobulin G (IgG) antibodies that are mediated through the family of Fcγ receptors (a class of Fc receptors that are members of the immunoglobulin superfamily and bind IgG), as well as the functions of sinusoidal endothelial cells of the liver.
Anderson's research has been funded by the National Institutes of Health for more than 40 years [1] for fundamental research into medicine and biology. His contributions to biomedical research and immunology fall into four major groups:
- The Fcγ Receptor (FcγR) family of molecules [2][3]
- IgG turnover mediated by the neonatal Fc receptor (FcRn)[4][5][6][7]
- Albumin turnover mediated by FcRn[8][9]
- Small particle clearance from blood by liver sinusoidal endothelium (LSEC)[10][11]
Anderson's work on identifying and characterizing the the high affinity (CD64) and low affinity (CD32) Fc receptors for IgG on human monocytes and other cells has been influential [12] [13] Anderson, along with Dartmouth University faculty Paul Guyre, PhD [14], and Michael Fanger, PhD [15] developed and patented monoclonal antibodies 32 and IV.3, which bind human CD64 and CD32 respectively (US Patent US4954617A awarded in 1990) . Guyre and Fanger founded Medarex, which produced and marketed these two monoclonal antibodies. Medarex has since been acquired by Bristol-Myers Squibb for 2.4 billion US$ [16]
These two antibodies, masb 32 and IV.3, have since been used as reference activating or blocking reagents in multiple subsequent studies on FcγR, e.g., work on soluble FcgRII [17] by Hogarth [18] and a study on anaphylaxis and thrombocytopenia in mice[19].
Anderson received his MD from the University of Chicago in 1964 and studied chemistry and biology, as an undergraduate, at the University of Arizona and Brown University respectively [20]. After postdoctoral work with Richard Farr and Percy Minden[21], and Howard Grey[22] at the National Jewish Hospital in Denver, CO he was tenured at the University of Rochester in 1982. In 1986 he moved to The Ohio State University (OSU) in Columbus, OH as Professor in the Departments of Internal Medicine, Molecular and Cellular Biochemistry, and Molecular Genetics.
Notable among the students, postdoctoral fellows, and collaborators of Anderson laboratory is Jan GJ Van de Winkel[23], President and Chief Executive Officer of Genmab.
Early life and education
- M.D., University of Chicago, 1964
- Biochemistry Graduate Program, University of Chicago, 1965
- Medicine Internship: University of Colorado, 1965-1966
- Vietnam War Doctor Draft, 1966-1969
- Medicine Residency: University of Colorado, 1969-1971
- Clinical Immunology Fellowship: National Jewish Center and U. Colorado, 1973-1974.
- Immunochemistry Fellowship: National Jewish Center, 1971-1977
Honors
- Leukemia Society of America Special Fellow 1975-77
- Research Career Development Award, NIAID 1979-84
- Medical Biochemistry Study Section, DRG, NIH 1987-91
- University Distinguished Scholar Award, OSU 1994
References
- ^ Ohio State University, College of Medicine News article on $1.7M Grant awarded to Anderson in 2014
- ^ Anderson CL, Looney RJ. 1986. Human leukocyte IgG Fc receptors. Immunol Today. 1986 Sep;7(9):264-6. doi: 10.1016/0167-5699(86)90007-1. PMID: 25290629
- ^ Anderson CL. 1989. Human IgG Fc receptors. Clin. Immunol. Immunopathol. 1989 Nov;53(2 Pt 2):S63-71. Review. PMID: 2529071
- ^ Junghans RP, and Anderson CL. 1996. The protection receptor for IgG catabolism is the b2- microglobulin-containing neonatal intestinal transport receptor. Proc. Natl. Acad. Sci. 93:5512-5516.
- ^ Brambell FW (1969) The transmission of immune globulins from the mother to the foetal and newborn young.Proc Nutr Soc. 1969 Mar;28(1):35-41.
- ^ Ward ES, Ober RJ (2015) Commentary: “There’s been a flaw in our thinking”. Front. Immunol., 16 July 2015 | https://doi.org/10.3389/fimmu.2015.00351
- ^ Anderson CL (2014) Commentary: “There’s been a flaw in our thinking”. Front Immunol. 2014 Oct 31;5:540. doi: 10.3389/fimmu.2014.00540. eCollection 2014
- ^ Chaudhury C,Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, and Anderson CL. 2003. The MHC-related Fc receptor for IgG binds albumin and prolongs its lifespan. J. Exp. Med. 197:315- 322
- ^ Sand et al. (2014) Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics Front Immunol. 2014; 5: 682
- ^ Anderson CL. 2015. The liver sinusoidal endothelium reappears after being eclipsed by the Kupffer cell: a 20th century biological delusion corrected. J Leukoc Biol. 98(6):875-6. PMID: 26628636
- ^ Anderson CL, Ganesan LP, Robinson JM. 2015. The biology of the classical Fcγ receptors in non-hematopoietic cells. Immunol Rev. 2015. 268(1):236-40. PMID: 26497524
- ^ The high-affinity Fc gamma RI on PMN: regulation of expression and signal transduction Hoffmeyer F, Witte K, Schmidt RE (1997). Immunology. 1997 Dec;92(4):544-52
- ^ Signal transduction via Fc gamma R and Mac-1 alpha-chain in monocytes and polymorphonuclear leucocytes Gadd SJ, Eher R, Majdic O, Knapp W (1994) Immunology. 1994 Apr;81(4):611-7
- ^ http://celdaramedical.com/site-administrator/2016-04-19-14-06-54/110-paul-guyre
- ^ http://celdaramedical.com/site-administrator/2016-04-19-14-06-54/109-michael-w-fanger
- ^ Allison M. Bristol-Myers Squibb swallows last of antibody pioneers. Nat Biotechnol. 2009 Sep;27(9):781-3. doi: 10.1038/nbt0909-781. PMID 19741612
- ^ Wines BD1, Gavin A, Powell MS, Steinitz M, Buchanan RR, Mark Hogarth P (2003) and Soluble FcγRIIa inhibits rheumatoid factor binding to immune complexes. Immunology. 2003 Jun;109(2):246-54
- ^ https://www.burnet.edu.au/staff_members/182_mark_hogarth
- ^ Meyer T, Robles-Carrillo L, Davila M, Brodie M, Desai H, Rivera-Amaya M, Francis JL, Amirkhosravi A. (2015) CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice. Blood 2015 126:2230-2238; doi: https://doi.org/10.1182/blood-2015-04-638684
- ^ Clark Anderson Internal Medicine OSU
- ^ Farr R. and Minden P. (1968) Biology of the mycobacterioses. Ann N Y Acad Sci. 1968 Sep 5;154(1):107-14. PMID: 4909582
- ^ National Academy of Sciences member page for Howard M. Grey
- ^ http://www.genmab.com/about-us/senior-leadership/jan-g-j-van-de-winkel
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