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P2Y12

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purinergic receptor P2Y, G-protein coupled, 12
Identifiers
SymbolP2RY12
NCBI gene64805
HGNC18124
OMIM600515
PDB1VZ1, 1Y9C 1T78, 1VZ1, 1Y9C
RefSeqNM_022788
UniProtQ9H244
Other data
LocusChr. 3 q24-q25
Search for
StructuresSwiss-model
DomainsInterPro

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) found on the cell surface of blood platelet cells. It is an important regulator in blood platelet coagulation. The drug Clopidogrel binds to this receptor and is marketed as a platelet anticoagulant. In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration, in which this method of platelet anticoagulant therapy was used [1].