Laurence Rahme
Laurence G. Rahme | |
|---|---|
| Born | |
| Nationality | Greek, American |
| Alma mater | University of Naples, Italy (B.Sc. in Biology) Institute of Genetics and Biophysics C.N.R., University of Naples, Italy (M.S. in Molecular Genetics) University of California at Berkeley (Ph.D. in Microbiology) Massachusetts General Hospital and Harvard Medical School (post-doctoral fellowship) |
| Known for | antivirulence drugs, alternatives to antibiotics |
| Awards | American Academy of Microbiology Fellow (2017) |
| Scientific career | |
| Fields | Microbiology, Molecular Genetics, Immunology |
| Institutions | Massachusetts General Hospital and Harvard Medical School (1992-present) Shriners Hospitals for Children (1997-present) |
Laurence G. Rahme is Professor of Surgery and Molecular Biology at Massachusetts General Hospital (MGH) and Professor of Microbiology at Harvard Medical School (HMS).[1][2] At Massachusetts General Hospital, she also holds the title of Director of the Molecular Surgical Laboratory. Additionally, she is Senior Scientific Staff at Shriners Hospitals for Children-Boston.[3] She received her B.S. from the University of Naples, Italy, her M.S. from the Institute of Genetics and Biophysics C.N.R., University of Naples, Italy, and her Ph.D. from the University of California at Berkeley. She completed her postdoctoral fellowship at Massachusetts General Hospital/Harvard Medical School. She was also awarded an honorary degree from Harvard Medical School. Laurence Rahme has published an extensive number (100+) of scientific journal articles[4] and patents[5][6] with applications to treat antibiotic resistant bacterial infections and strategies to limit the emergence of antibiotic resistant strains. She has also been on, or currently serves on Advisory and Editorial Boards of numerous scientific journals and on review panels at the National Institutes of Health (NIH), National Science Foundation (NSF) and the Department of Defense (DoD). Her numerous prizes and honors include being elected as an American Academy of Microbiology Fellow in 2017.[7][8]
Laurence Rahme is best known for her pioneering work on systems used by bacteria to regulate its virulence and host response to infection.[9] The study of the problematic Pseudomonas aeruginosa bacteria in the laboratory setting internationally today often uses the multi-host infection models developed using the "PA14" strain by Laurence Rahme.[10][11] Using her established system, she uncovered that the multiple virulence factor regulator (MvFR) is a key regulator of bacterial quorum-sensing signaling and pathogenesis in various host organisms.[12][13] Based on these findings, she developed anti-virulence drugs as an alternative to antibiotics[14] and founded Spero Therapeutics in Cambridge, MA.[15][16][17][18]
References
- ^ "Loop - Laurence Rahme". loop.frontiersin.org.
- ^ https://www.massgeneral.org/surgery/assets/pdfs/surgery-news-winter2018.pdf
- ^ "Spotlight on Shriners Hospitals for Children — Boston research faculty". www.shrinershospitalsforchildren.org.
- ^ pubmeddev. "rahme l - PubMed - NCBI". www.ncbi.nlm.nih.gov.
- ^ "Laurence Rahme Inventions, Patents and Patent Applications - Justia Patents Search". patents.justia.com.
- ^ "Laurence G. Rahme Inventions, Patents and Patent Applications - Justia Patents Search". patents.justia.com.
- ^ "Awards and Honors April 2017". Massachusetts General Hospital.
- ^ https://ecor.mgh.harvard.edu/content/files/SAC2018_Celebration_of_Science.pdf
- ^ Strauss, Evelyn (22 December 2000). "Simple Hosts May Help Reveal How Bacteria Infect Cells". Science. 290 (5500): 2245–7. doi:10.1126/science.290.5500.2245. PMID 11188717.
- ^ Rahme, Laurence G.; Ausubel, Frederick M. (15 November 1997). "Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors". Proceedings of the National Academy of Sciences of the United States of America. 94 (24): 13245–50. Bibcode:1997PNAS...9413245R. doi:10.1073/pnas.94.24.13245. PMC 24294. PMID 9371831.
- ^ Apidianakis, Yiorgos; Rahme, Laurence G. (13 August 2009). "Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection". Nature Protocols. 4 (9): 1285–94. doi:10.1038/nprot.2009.124. PMID 19680242.
- ^ Rahme, Laurence G.; Ausubel, Frederick M. (1 August 2000). "Plants and animals share functionally common bacterial virulence factors". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8815–21. Bibcode:2000PNAS...97.8815R. doi:10.1073/pnas.97.16.8815. PMC 34017. PMID 10922040.
- ^ Cao, Hui; Rahme, Laurence G. (4 December 2001). "A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism". Proceedings of the National Academy of Sciences of the United States of America. 98 (25): 14613–8. Bibcode:2001PNAS...9814613C. doi:10.1073/pnas.251465298. PMC 64730. PMID 11724939.
- ^ Starkey, Melissa; Lepine, Francois; Maura, Damien; Bandyopadhaya, Arunava; Lesic, Biljana; He, Jianxin; Kitao, Tomoe; Righi, Valeria; Milot, Sylvain; Tzika, Aria; Rahme, Laurence (21 August 2014). "Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity". PLoS Pathogens. 10 (8): e1004321. doi:10.1371/journal.ppat.1004321. PMC 4140854. PMID 25144274.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Servick, Kelly (22 May 2015). "The drug push". Science. 348 (6237): 850–853. doi:10.1126/science.348.6237.850. PMID 25999488 – via science.sciencemag.org.
- ^ Timmerman, Luke. "Merck, New England Patriots Boss Bet $30M On Antibiotics Startup Spero". Forbes.
- ^ "Fierce 15: Two Partners Spinoffs Awarded Honors". Partners HealthCare. 2 December 2014.
- ^ "What You Need to Know About Spero". BioSpace.
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