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Athel Cornish-Bowden

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This is an old revision of this page, as edited by Rhodydog (talk | contribs) at 20:46, 9 August 2019 (→Education and Career). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

  • Comment: He may well be notable but there are still no independent sources for anything, the education and career section still fails verification with no supporting sources for the content? Theroadislong (talk) 07:13, 9 August 2019 (UTC)

It is true I don’t have evidence for example that he was at Oxford as an undergraduate or he was born Devon other that what it says in is cv so I can remove items like this. We do have evidence through published papers that he was a graduate at oxford. I’ll remove material I don’t have specific secondary evidence for. Will that be satisfactory? I’m trying my best to figure what you want but comments are (and not trying to be rude) a little vague. Rhodydog (talk) 20:28, 9 August 2019 (UTC)

  • Comment: All the sources are to his own books, Wikipedia requires in-depth coverage in independent reliable sources. Theroadislong (talk) 19:55, 4 August 2019 (UTC)
Athel Cornish-Bowden
Born(1943-04-03)April 3, 1943
Ashburton, Devon, England
NationalityBritish
Alma materUniversity of Oxford
Known forEnzyme Kinetics, Metabolic Control Analysis
Awardsmember of the Academia Chilena de Ciencias. Facultad de Ciencias, Universidad de Chile, Santiago, Chile
Scientific career
InstitutionsCentre National de la Recherche Scientifique, University of Birmingham
Thesis Studies of Pepsin Catalysis  (1967)
Doctoral advisorJeremy R. Knowles
Websitebip.cnrs-mrs.fr/bip10/homepage.htm

Athel Cornish-Bowden (3 April 1943 –) is a British biochemist who obtained his education at Oxford in Britain, became a lecturer and senior lecturer at the University of Birmingham and finally Directeur de Recherche (Émérite), Centre National de la Recherche Scientifique, Marseilles, France. Cornish-Bowden is most well known for his numerous textbooks, particularly those on enzyme kinetics and his work on metabolic control analysis.

Education and Career

Athel Cornish-Bowden worked on pepsin catalysis.[1]. This began a life long pursuit of work on enzyme catalysis[2] and in later years work on the control of metabolism[3]. More recently he has also turned his attention to work related to the origin and nature of life[4].He worked with [5] with Daniel E. Koshland Jr..

Research

Cornish-Bowden has authored over 200 peer-reviewed papers and nine textbooks on topics related to enzyme kinetics, mathematics and historical perspectives in science. Some of his textbooks, particularly those on enzyme kinetics, have been an authoritative source for students and researchers for many decades.

Cornish-Bowden's research can be divided into three primary areas: Enzyme kinetics, metabolic control and the origin of life. The following lists some of the topics and selected references to the work carried out and published by Cornish-Bowden:

Mechanisms of Pepsin Catalysis[6][7][8]

Binding of ligands to Proteins[9][10][11][12]

Kinetics of nitrite reductase[13][14][15]

Kinetics of nitrate reductase[16]

The evolution of macromolecules[17][18]

Properties of multienzyme systems[19][20][21][22][23]

The theory of self-organizing systems[24][25][26][27][28]

His current interests include the definition of life and the capacity for life to self-organize.

Cornish-Bowden is most well known for his introduction of the direct-linear plot for estimating enzyme parameters[29], his work on Hexokinase evolution and kinetics[30], and his insight into the control and regulation of metabolism[31]

A large number of secondary sources have cited Cornish-Bowden's work including:

  • Lars Nielsen (with h-index of 56 and 11,502 citations) who cited Cornish-Bowden's work in his paper: "Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks".[32]
  • Douglas Kell (with h-index of 109 and 49,323 citations) who cited Cornish-Bowden's work in his paper: "Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases:[33]
  • Vassily Hatzimanikatis (with h-index 48 and 9,513 citations) who cited Cornish-Bowden's work in his paper: "Modeling of uncertainties in biochemical reactions"[34]
  • Pedro Mendes (with h-index 52, and 20,037 citations) who cited Cornish-Bowden's work in his paper: 'Modelling and simulation for metabolomics data analysis"[35]
  • Stefan Schuster (with h-index 49, and 14,854 citations) who cited Cornish-Bowden's work in the paper: "A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks"[36]
  • Barbara Bakker (with h-index 40, and 7,745 citations) who cited Cornish-Bowden's work in her paper: "What controls glycolysis in bloodstream form Trypanosoma brucei?"[37]

Selection of Influential Publications

  • Cornish-Bowden, Athel; Eisenthal, Robert (1974). "The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters". Biochemical Journal. 139 (3): 715–720. doi:10.1042/bj1390715. PMID 4854723. Cited 1716 times (Aug, 2019)
  • Storer, AC; Darlison, MG; Cornish-Bowden, A (November 1975). "The nature of experimental error in enzyme kinetic measurments". The Biochemical journal. 151 (2): 361–7. doi:10.1042/bj1510361. PMID 1218083. Cited 98 times (Aug 2019)
  • Storer, AC; Cornish-Bowden, A (1 October 1976). "Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations". The Biochemical journal. 159 (1): 7–14. doi:10.1042/bj1590007. PMID 999645. Cited 143 times (Aug 2019)
  • Storer, AC; Cornish-Bowden, A (1 July 1977). "Kinetic evidence for a 'mnemonical' mechanism for rat liver glucokinase". The Biochemical journal. 165 (1): 61–9. doi:10.1042/bj1650061. PMID 889576. Cited 139 times (Aug 2019)
  • Cornish-Bowden, A (14 July 1986). "Why is uncompetitive inhibition so rare? A possible explanation, with implications for the design of drugs and pesticides". FEBS letters. 203 (1): 3–6. doi:10.1016/0014-5793(86)81424-7. PMID 3720956. Cited 137 times (Aug 2019)
  • Eisenthal, R; Cornish-Bowden, A (6 March 1998). "Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness". The Journal of biological chemistry. 273 (10): 5500–5. doi:10.1074/jbc.273.10.5500. PMID 9488673.{{cite journal}}: CS1 maint: unflagged free DOI (link) Cited 96 times (Aug 2019)
  • Cárdenas, ML; Cornish-Bowden, A; Ureta, T (5 March 1998). "Evolution and regulatory role of the hexokinases". Biochimica et biophysica acta. 1401 (3): 242–64. doi:10.1016/s0167-4889(97)00150-x. PMID 9540816. Cited 287 times (Aug 2019)
  • Hucka, M; Finney, A; Sauro, HM; Bolouri, H; Doyle, JC; Kitano, H; Arkin, AP; Bornstein, BJ; Bray, D; Cornish-Bowden, A; Cuellar, AA; Dronov, S; Gilles, ED; Ginkel, M; Gor, V; Goryanin, II; Hedley, WJ; Hodgman, TC; Hofmeyr, JH; Hunter, PJ; Juty, NS; Kasberger, JL; Kremling, A; Kummer, U; Le Novère, N; Loew, LM; Lucio, D; Mendes, P; Minch, E; Mjolsness, ED; Nakayama, Y; Nelson, MR; Nielsen, PF; Sakurada, T; Schaff, JC; Shapiro, BE; Shimizu, TS; Spence, HD; Stelling, J; Takahashi, K; Tomita, M; Wagner, J; Wang, J; SBML, Forum. (1 March 2003). "The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models". Bioinformatics (Oxford, England). 19 (4): 524–31. doi:10.1093/bioinformatics/btg015. PMID 12611808. Cited 3057 times (Aug 2019)
  • Letelier, JC; Soto-Andrade, J; Guíñez Abarzúa, F; Cornish-Bowden, A; Luz Cárdenas, M (21 February 2006). "Organizational invariance and metabolic closure: analysis in terms of (M,R) systems". Journal of theoretical biology. 238 (4): 949–61. doi:10.1016/j.jtbi.2005.07.007. PMID 16122760. Cited 269 times (Aug 2019)
  • Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744. Cited 3120 times (Aug 2012)

Editorial Work

1976–1980 Member of the Editorial Board of the Biochemical Journal, London, UK

1980–1983 Deputy Chairman of the Editorial Board of the Biochemical Journal, London, UK

1982–present Member of the Editorial Board of the Journal of Theoretical Biology, London, UK

1984–present Member of the Editorial-Advisory Board of the FEBS Journal (formerly known as the European Journal of Biochemistry), Cambridge, UK

1993–2001 Editorial Adviser to the Biochemical Journal, London, UK

1995–1999 Member of the Editorial Board of Biological Research, Santiago, Chile

1998–2004 Member of the Editorial Board of the Journal of Biosciences, Bangalore, India

2013–2015 Member of the Editorial Board of Biochemistry and Molecular Biology Education, USA

International Committees

1979–1982 Member of a panel of the International Union of Biochemistry for preparing Recommendations on Symbolism and Terminology in Enzyme Kinetics; Convenor of the panel, 1980–1982; drafter of the report published in Arch. Biochem. Biophys. 224, 732–740 (1983), Biochem. J. 213, 561-571 (1983), and Eur. J. Biochem. 128, 281-291 (1982)

1983–1989 Secretary, IUB – IUPAC Joint Commission on Biochemical Nomenclature and of the IUB Nomenclature Committee

1989–1991 Member, IUB – IUPAC Joint Commission on Biochemical Nomenclature

1990–1996 Director, Portland Press Limited, London, UK

1992–1996 Director, Portland Press Incorporated, Chapel Hill, North Carolina, USA

1995–1996 Chairman, IUBMB – IUPAC Joint Commission on Biochemical Nomenclature

1995–1996 Chairman, Nomenclature Committee of the IUBMB

1999 Member of an Expert Panel of the Fundação para a Ciência e a Tecnologia to evaluate units of research in chemistry in Portugal.

2002–2005 Member, FEBS Publications Committee

2003 Member of an Expert Panel of the Fundação para a Ciência e a Tecnologia to evaluate units of research in chemistry in Portugal.

2007–present Chairman, International Scientific Committee of the Institute of Cellular Metabolism (Instituto del Metabolismo celular), Tenerife, Spain

2010–present Member, FEBS Publications Committee

Personal Life

Athel Cornish-Bowden is married to Dr María Luz Cárdenas and has three daughters.[citation needed]

Books

  • Cornish-Bowden, Athel (1976). Principles of Enzyme Kinetics. London: Butterworths. ISBN 0408707216.
  • Cornish-Bowden, Athel (1979). Fundamentals of Enzyme Kinetics. London: Butterworths.
  • Cornish-Bowden, Athel (1995). Fundamentals of Enzyme Kinetics (2 ed.). London: Butterworths. ISBN 1 85578 072 0.
  • Cornish-Bowden, Athel (1996). Analysis of Enzyme Kinetic Datas (4 ed.). London: Oxford University Press. ISBN 0-19-854877-X.
  • Cornish-Bowden, Athel (1999). Basic Mathematics for Biochemists (2 ed.). Oxford and New York: Oxford University Press. ISBN 0-19-854877-X.
  • Cornish-Bowden, Athel (2004). Fundamentals of Enzyme Kinetics (3 ed.). London: Butterworths. ISBN 0408707216.
  • Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744.
  • Cornish-Bowden, Athel (2016). Biochemical Evolution: the Pursuit of Perfection (2 ed.). Garland Science. ISBN 978-0-8153-4552-7.

References

  1. ^ Cornish-Bowden, AJ; Greenwell, P; Knowles, JR (June 1969). "The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical journal. 113 (2): 369–75. doi:10.1042/bj1130369. PMID 4897200.
  2. ^ Cornish-Bowden, A; Connolly, BA; Gregoriou, M; Holroyde, MJ; Storer, AC; Trayer, IP (December 1979). "Mammalian hexokinases: a system for the study of co-operativity in monomeric enzymes". Archivos de biologia y medicina experimentales. 12 (5): 581–5. PMID 552244.
  3. ^ Hofmeyr, JH; Cornish-Bowden, A (15 August 1991). "Quantitative assessment of regulation in metabolic systems". European journal of biochemistry. 200 (1): 223–36. doi:10.1111/j.1432-1033.1991.tb21071.x. PMID 1879427.
  4. ^ Cornish-Bowden, A; Cárdenas, ML (7 December 2017). "Life before LUCA". Journal of theoretical biology. 434: 68–74. doi:10.1016/j.jtbi.2017.05.023. PMID 28536033.
  5. ^ Cornish-Bowden, A; Koshland DE, Jr (18 August 1970). "A general method for the quantitative determination of saturation curves for multisubunit proteins". Biochemistry. 9 (17): 3325–36. doi:10.1021/bi00819a006. PMID 4330854.
  6. ^ Cornish-Bowden, AJ; Knowles, JR (June 1969). "The pH-dependence of pepsin-catalysed reactions". The Biochemical journal. 113 (2): 353–62. doi:10.1042/bj1130353. PMID 4897198.
  7. ^ Cornish-Bowden, AJ; Knowles, JR (June 1969). "The pH-dependence of pepsin-catalysed reactions". The Biochemical journal. 113 (2): 353–62. doi:10.1042/bj1130353. PMID 4897198.
  8. ^ Cornish-Bowden, AJ; Greenwell, P; Knowles, JR (June 1969). "The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical journal. 113 (2): 369–75. doi:10.1042/bj1130369. PMID 4897200.
  9. ^ Cornish-Bowden, A; Koshland DE, Jr (10 December 1970). "The influence of binding domains on the nature of subunit interactions in oligomeric proteins. Application to unusual kinetic and binding patterns". The Journal of biological chemistry. 245 (23): 6241–50. PMID 5484808.
  10. ^ Cornish-Bowden, A; Koshland DE, Jr (18 August 1970). "A general method for the quantitative determination of saturation curves for multisubunit proteins". Biochemistry. 9 (17): 3325–36. doi:10.1021/bi00819a006. PMID 4330854.
  11. ^ Cornish-Bowden, A; Koshland DE, Jr (25 June 1975). "Diagnostic uses of the Hill (Logit and Nernst) plots". Journal of molecular biology. 95 (2): 201–12. doi:10.1016/0022-2836(75)90390-3. PMID 171413.
  12. ^ Cornish-Bowden, A (May 1975). "Letter: The physiological significance of negative co-operativity". Journal of theoretical biology. 51 (1): 233–5. doi:10.1016/0022-5193(75)90149-6. PMID 1142781.
  13. ^ Coleman, KJ; Cornish-Bowden, A; Cole, JA (1 November 1978). "Purification and properties of nitrite reductase from Escherichia coli K12". The Biochemical journal. 175 (2): 483–93. doi:10.1042/bj1750483. PMID 217342.
  14. ^ Jackson, RH; Cole, JA; Cornish-Bowden, A (1 May 1982). "The steady state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K12. The reduction of single-electron acceptors". The Biochemical journal. 203 (2): 505–10. doi:10.1042/bj2030505. PMID 6288003.
  15. ^ Jackson, RH; Cole, JA; Cornish-Bowden, A (1 May 1982). "The steady state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K12. The reduction of single-electron acceptors". The Biochemical journal. 203 (2): 505–10. doi:10.1042/bj2030505. PMID 6288003.
  16. ^ Buc, J; Santini, CL; Blasco, F; Giordani, R; Cárdenas, ML; Chippaux, M; Cornish-Bowden, A; Giordano, G (15 December 1995). "Kinetic studies of a soluble alpha beta complex of nitrate reductase A from Escherichia coli. Use of various alpha beta mutants with altered beta subunits". European journal of biochemistry. 234 (3): 766–72. doi:10.1111/j.1432-1033.1995.766_a.x. PMID 8575433.
  17. ^ Cornish-Bowden, A (15 February 1976). "The effect of natural selection on enzymic catalysis". Journal of molecular biology. 101 (1): 1–9. doi:10.1016/0022-2836(76)90062-0. PMID 1255718.
  18. ^ Cornish-Bowden, A (1985). "Are introns structural elements or evolutionary debris?". Nature. 313 (6002): 434–5. doi:10.1038/313434b0. PMID 3969152.
  19. ^ Hofmeyr, JH; Cornish-Bowden, A (15 August 1991). "Quantitative assessment of regulation in metabolic systems". European journal of biochemistry. 200 (1): 223–36. doi:10.1111/j.1432-1033.1991.tb21071.x. PMID 1879427.
  20. ^ Cornish-Bowden, A; Hofmeyr, JH (1 March 1994). "Determination of control coefficients in intact metabolic systems". The Biochemical journal. 298 ( Pt 2): 367–75. doi:10.1042/bj2980367. PMID 8135743.
  21. ^ Hofmeyr, JH; Cornish-Bowden, A (7 October 1996). "Co-response analysis: a new experimental strategy for metabolic control analysis". Journal of theoretical biology. 182 (3): 371–80. doi:10.1006/jtbi.1996.0176. PMID 8944170.
  22. ^ Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248.
  23. ^ Cornish-Bowden, A; Hofmeyr, JH (21 May 2002). "The role of stoichiometric analysis in studies of metabolism: an example". Journal of theoretical biology. 216 (2): 179–91. doi:10.1006/jtbi.2002.2547. PMID 12079370.
  24. ^ Cornish-Bowden, A; Cárdenas, ML; Letelier, JC; Soto-Andrade, J; Abarzúa, FG (December 2004). "Understanding the parts in terms of the whole". Biology of the cell. 96 (9): 713–7. doi:10.1016/j.biolcel.2004.06.006. PMID 15567526.
  25. ^ Cornish-Bowden, A; Cárdenas, ML (October 2007). "Organizational invariance in (M,R)-systems". Chemistry & biodiversity. 4 (10): 2396–406. doi:10.1002/cbdv.200790195. PMID 17955465.
  26. ^ Cornish-Bowden, A; Cárdenas, ML (7 June 2008). "Self-organization at the origin of life". Journal of theoretical biology. 252 (3): 411–8. doi:10.1016/j.jtbi.2007.07.035. PMID 17889904.
  27. ^ Cárdenas, ML; Letelier, JC; Gutierrez, C; Cornish-Bowden, A; Soto-Andrade, J (7 March 2010). "Closure to efficient causation, computability and artificial life". Journal of theoretical biology. 263 (1): 79–92. doi:10.1016/j.jtbi.2009.11.010. PMID 19962389.
  28. ^ Cárdenas, ML; Letelier, JC; Gutierrez, C; Cornish-Bowden, A; Soto-Andrade, J (7 March 2010). "Closure to efficient causation, computability and artificial life". Journal of theoretical biology. 263 (1): 79–92. doi:10.1016/j.jtbi.2009.11.010. PMID 19962389.
  29. ^ Eisenthal, R; Cornish-Bowden, A (June 1974). "The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters". The Biochemical journal. 139 (3): 715–20. doi:10.1042/bj1390715. PMID 4854723.
  30. ^ Cárdenas, ML; Cornish-Bowden, A; Ureta, T (5 March 1998). "Evolution and regulatory role of the hexokinases". Biochimica et biophysica acta. 1401 (3): 242–64. doi:10.1016/s0167-4889(97)00150-x. PMID 9540816.
  31. ^ Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248.
  32. ^ . PMID 28916392. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  33. ^ Kell, DB (8 January 2009). "Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases". BMC medical genomics. 2: 2. doi:10.1186/1755-8794-2-2. PMID 19133145.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  34. ^ Mišković, L; Hatzimanikatis, V (February 2011). "Modeling of uncertainties in biochemical reactions". Biotechnology and bioengineering. 108 (2): 413–23. doi:10.1002/bit.22932. PMID 20830674.
  35. ^ Mendes, P; Camacho, D; de la Fuente, A (December 2005). "Modelling and simulation for metabolomics data analysis". Biochemical Society transactions. 33 (Pt 6): 1427–9. doi:10.1042/BST20051427. PMID 16246137.
  36. ^ Schuster, S; Fell, DA; Dandekar, T (March 2000). "A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks". Nature biotechnology. 18 (3): 326–32. doi:10.1038/73786. PMID 10700151.
  37. ^ Bakker, BM; Michels, PA; Opperdoes, FR; Westerhoff, HV (21 May 1999). "What controls glycolysis in bloodstream form Trypanosoma brucei?". The Journal of biological chemistry. 274 (21): 14551–9. doi:10.1074/jbc.274.21.14551. PMID 10329645.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Category:Systems biologists Category:Theoretical biologists Category:1943 births Category:Living people Category:British biochemists Category:Alumni of Wadham College, Oxford Category:Academics of the University of Oxford

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