Staphylopine dehydrogenase

In enzymology,a staphylopine synthase (EC 1.5.1.52) is an enzyme that catalyzes NADPH-dependent reductive condensation of pyruvate to the intermediate (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, which is the last step in the biosynthesis of the metallophore staphylopine^[1]. The chemical reaction is

H₂O + NADP⁺ + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H⁺ + NADPH + pyruvate^[2]

Alternative name(s): staphylopine dehydrogenase.

^ Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R. (2016-05-26). "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus". Science. 352 (6289): 1105–1109. doi:10.1126/science.aaf1018. ISSN 0036-8075.
^ "cntM - Staphylopine synthase - Staphylococcus aureus (strain Mu50 / ATCC 700699) - cntM gene & protein". www.uniprot.org. Retrieved 2019-12-03.

[1] Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R. (2016-05-26). "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus". Science. 352 (6289): 1105–1109. doi:10.1126/science.aaf1018. ISSN 0036-8075.

[2] "cntM - Staphylopine synthase - Staphylococcus aureus (strain Mu50 / ATCC 700699) - cntM gene & protein". www.uniprot.org. Retrieved 2019-12-03.

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