Nabitan: Difference between revisions

{{Short description|Synthetic cannabinoid}}

{{Drugbox

| verifiedrevid = 421099167

| IUPAC_name = 5,5-Dimethyl-8-(3-methyloctan-2-yl)-2-(prop-2-yn-1-yl)-1,3,4,5-tetrahydro-2''H''-[1]benzopyrano[4,3-''c'']pyridin-10-yl 4-(piperidin-1-yl)butanoate

| width = 180

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| tradename =

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| metabolism =

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<!--Identifiers-->

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 66556-74-9

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = JO7BOR6B3O

| ATC_prefix = none

| PubChem = 39503

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| C=35 | H=52 | N=2 | O=3

'''Nabitan''' ('''Nabutam''', '''Benzopyranoperidine''', '''SP-106''', '''Abbott 40656''') is a [[Chemical synthesis|synthetic]] [[cannabinoid]] [[Analog (chemistry)|analog]] of [[dronabinol]] (Marinol) and [[dimethylheptylpyran]].<ref>Razdan RK. The Total Synthesis of Cannabinoids. Wiley-Interscience 1980</ref> It exhibits [[antiemetic]] and [[analgesic]] effects, most likely by binding to and activating the CB₁ and CB₂ [[cannabinoid receptor]]s, and reduced [[intraocular pressure]] in animal tests, making it potentially useful in the treatment of [[glaucoma]].<ref>{{cite journal | vauthors = Razdan RK, Howes JF | title = Drugs related to tetrahydrocannabinol | journal = Medicinal Research Reviews | year = 1983 | volume = 3 | issue = 2 | pages = 119–46 | doi = 10.1002/med.2610030203 | pmid = 6134882 | s2cid = 31313909 }}</ref>

Nabitan has the advantage of being water-soluble, unlike most cannabinoid derivatives, and was researched for potential use as an analgesic or [[sedative]],<ref>{{cite journal | vauthors = Archer RA | title = The cannabinoids: therapeutic potentials | journal = Annual Reports in Medicinal Chemistry | year = 1974 | volume = 9 | pages = 253–9 | doi = 10.1016/s0065-7743(08)61448-7 | pmid = 12307093 }}</ref> although it was never developed for clinical use and is not currently used in medicine, as [[dronabinol]] or [[nabilone]] were felt to be more useful. However it is sometimes used in research into the potential therapeutic applications of cannabinoids.

== See also ==

* [[A-40174]] (SP-1)

* [[A-41988]]

* [[Dimethylheptylpyran]]

* [[Menabitan]]

{{Reflist}}

{{Hallucinogens}}

{{Cannabinoidergics}}

[[Category:Propargyl compounds]]

[[Category:Carboxylate esters]]

[[Category:Benzopyrans]]

[[Category:Nitrogen heterocycles]]

[[Category:Oxygen heterocycles]]

[[Category:Heterocyclic compounds with 3 rings]]

[[Category:1-Piperidinyl compounds]]

{{cannabinoid-stub}}