Phosphatidylinositol 3-phosphate: Difference between revisions
Content deleted Content added
Davebridges (talk | contribs) added link to PI(3,5)P2 |
Sayak Banik (talk | contribs) mNo edit summary |
||
| (31 intermediate revisions by 22 users not shown) | |||
| Line 1: | Line 1: | ||
{{Unreferenced stub|auto=yes|date=December 2009}} |
|||
{{Chembox |
{{Chembox |
||
| verifiedrevid = 402031007 |
|||
| ImageFile = Phosphatidylinositol-3-phosphate. |
| ImageFile = Phosphatidylinositol-3-phosphate.svg |
||
| ImageSize = |
| ImageSize = |
||
| IUPACName = |
| IUPACName = |
||
| OtherNames = sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate |
| OtherNames = sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate |
||
| |
|Section1={{Chembox Identifiers |
||
| Abbreviations = PtdIns3''P'' <br/> PtdIns(3)''P'' <br/> PI3P <br/> PI(3)P |
|||
| CASNo_Ref = {{cascite|correct|??}} |
|||
| CASNo = |
| CASNo = |
||
| PubChem = 6857403 |
| PubChem = 6857403 |
||
| SMILES = }} |
| SMILES = }} |
||
| |
|Section2={{Chembox Properties |
||
| Formula = C<sub>11</sub>H<sub>20</sub>O<sub>16</sub>P<sub>2</sub> |
| Formula = C<sub>11</sub>H<sub>20</sub>O<sub>16</sub>P<sub>2</sub> |
||
| MolarMass = 470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
| MolarMass = 470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
||
| Line 17: | Line 19: | ||
| BoilingPt = |
| BoilingPt = |
||
| Solubility = }} |
| Solubility = }} |
||
| |
|Section3={{Chembox Hazards |
||
| MainHazards = |
| MainHazards = |
||
| FlashPt = |
| FlashPt = |
||
| |
| AutoignitionPt = }} |
||
}} |
}} |
||
'''Phosphatidylinositol 3-phosphate''' ( |
'''Phosphatidylinositol 3-phosphate''' ('''PI3P''') is a [[phospholipid]] found in [[cell membranes]] that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III [[phosphoinositide 3-kinases]] (PI 3-kinases) activity on [[phosphatidylinositol]].<ref>{{cite journal | vauthors = Gillooly DJ, Simonsen A, Stenmark H | title = Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins | journal = The Biochemical Journal | volume = 355 | issue = Pt 2 | pages = 249–58 | date = April 2001 | pmid = 11284710 | pmc = 1221734 | doi = 10.1042/0264-6021:3550249 }}</ref> |
||
PtdIns3''P'' is |
PtdIns3''P'' is dephosphorylated by the [[myotubularin]] family of [[phosphatase]]s, on the D3 position of the inositol ring, and can be converted to [[Phosphatidylinositol 3,5-bisphosphate|PtdIns(3,5)''P''<sub>2</sub>]] by the lipid kinase [[PIKFYVE|PIKfyve]].<ref>{{cite journal | vauthors = De Craene JO, Bertazzi DL, Bär S, Friant S | title = Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways | journal = International Journal of Molecular Sciences | volume = 18 | issue = 3 | pages = 634 | date = March 2017 | pmid = 28294977 | pmc = 5372647 | doi = 10.3390/ijms18030634 | doi-access = free }}</ref> |
||
Both [[FYVE]] domains and [[PX domain]]s – found in proteins such as [[SNX1]], [[ |
Both [[FYVE domain|FYVE]] domains and [[PX domain]]s – found in proteins such as [[SNX1]], [[HGS (gene)|HGS]], and [[EEA1]] – bind to PtdIns3''P''.<ref>{{cite journal | vauthors = Stenmark H, Aasland R, Driscoll PC | title = The phosphatidylinositol 3-phosphate-binding FYVE finger | journal = FEBS Letters | volume = 513 | issue = 1 | pages = 77–84 | date = February 2002 | pmid = 11911884 | doi = 10.1016/s0014-5793(01)03308-7 | doi-access = | bibcode = 2002FEBSL.513...77S }}</ref> |
||
The majority of PtdIns3''P'' appears to be constitutively synthesised by the [[class III PI 3-kinase]], Vps34, at endocytic membranes. [[Class II PI 3-kinases]] also appear to synthesise PtdIns3''P'', their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3''P'' may be synthesised upon cell stimulation. |
The majority of PtdIns3''P'' appears to be constitutively synthesised by the [[class III PI 3-kinase]], [[PIK3C3]] (Vps34), at endocytic membranes. [[Class II PI 3-kinases]] also appear to synthesise PtdIns3''P'', their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3''P'' may be synthesised upon cell stimulation. |
||
== See also == |
|||
* [[Phosphatidylinositol 3-phosphate-binding protein 2]] |
|||
== References == |
|||
{{reflist}} |
|||
{{Phospholipids}} |
{{Phospholipids}} |
||
{{DEFAULTSORT:Phosphatidylinositol 3-Phosphate}} |
{{DEFAULTSORT:Phosphatidylinositol 3-Phosphate}} |
||
[[Category:Phospholipids]] |
[[Category:Phospholipids]] |
||
[[Category:EC 2.7.1]] |
|||
{{Transferase-stub}} |
{{Transferase-stub}} |
||
[[ru:Фосфатидилинозитол-3-фосфат]] |
|||