Prodilidine: Difference between revisions

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+{{Short description|Chemical compound}}
 {{Drugbox
+| verifiedrevid = 450105138
-| Verifiedfields = changed
-| verifiedrevid = 403510796
 | IUPAC_name = 1,2-dimethyl-3-phenylpyrrolidin-3-yl propionate
-| image = Prodilidine.png
+| image = Prodilidine.svg
 | width = 240
@@ Line 26: / Line 26: @@
 <!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 3734-17-6
 | ATC_prefix = none
@@ Line 32: / Line 33: @@
 | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
 | DrugBank =
-| UNII_Ref = {{fdacite|changed|FDA}}
+| UNII_Ref = {{fdacite|correct|FDA}}
 | UNII = P67JPY18WD
+| ChemSpiderID      = 18388
 <!--Chemical data-->
 | C=15 | H=21 | N=1 | O=2
-| molecular_weight = 247.333 g/mol
 | smiles = CCC(=O)OC1(CCN(C1C)C)C2=CC=CC=C2
+| StdInChI          = 1S/C15H21NO2/c1-4-14(17)18-15(10-11-16(3)12(15)2)13-8-6-5-7-9-13/h5-9,12H,4,10-11H2,1-3H3
+| StdInChIKey       = LUKSBMJXPCFBKO-UHFFFAOYSA-N
 | synonyms =
 }}
-'''Prodilidine''' is an [[opioid]] [[analgesic]] which is a ring-contracted analogue of [[prodine]]. It has around the same efficacy as [[codeine]], but is only around 1/3 the potency, and has little [[abuse potential]].<ref>[http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1964-01-01_1_page005.html Fraser HF. Addictiveness of 1,2-dimethyl,3-phenyl,3-propionoxy pyrrolidine hydrochloride (ARC I-O-1) ''UNODC Bulletin on Narcotics'' 1964 Issue 1.]</ref><ref>Splitter SR. Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic). ''Current Therapeutic Research, Clinical and Experimental''. 1961 Nov;3:472-7. PMID 13915874</ref><ref>Kissel JW, Albert JR, Boxill GC. The pharmacology of prodilidine hydrochloride, a new analgetic agent. ''Journal of Pharmacology and Experimental Therapeutics''. 1961 Dec;134:332-40. PMID 14456453</ref><ref>Weikel JH Jr, Labudde JA. Absorption, excretion and fate of prodilidine. ''Journal of Pharmacology and Experimental Therapeutics''. 1962 Dec;138:392-8. PMID 13999550</ref><ref>Batterman RC, Mouratoff GJ, Kaufman JE. Prodilidine Hydrochloride: A new moderately potent analgesic. ''American Journal of the Medical Sciences''. 1964 Jan;247:62-8. PMID 14106881</ref>
+'''Prodilidine''' is an [[opioid]] [[analgesic]] which is a ring-contracted analogue of [[prodine]]. It has around the same analgesic efficacy as [[codeine]], but is only around 1/3 the potency (100mg prodilidine is equivalent to 3mg oral morphine). It has little [[abuse potential]].<ref>{{cite journal | url = http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1964-01-01_1_page005.html | vauthors = Fraser HF | title = Addictiveness of 1,2-dimethyl,3-phenyl,3-propionoxy pyrrolidine hydrochloride (ARC I-O-1) | journal = UNODC Bulletin on Narcotics | date = January 1964 | volume = 16| issue = 1 | pages = 37–43 }}</ref><ref>{{cite journal | vauthors = Splitter SR | title = Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic) | journal = Current Therapeutic Research, Clinical and Experimental | volume = 3 | pages = 472–7 | date = November 1961 | pmid = 13915874 }}</ref><ref>{{cite journal | vauthors = Kissel JW, Albert JR, Boxill GC | title = The pharmacology of prodilidine hydrochloride, a new analgetic agent | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 134 | pages = 332–40 | date = December 1961 | pmid = 14456453 }}</ref><ref>{{cite journal | vauthors = Weikel JH, Labudde JA | title = Absorption, excretion and fate of prodilidine | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 138 | pages = 392–8 | date = December 1962 | pmid = 13999550 }}</ref><ref>{{cite journal | vauthors = Batterman RC, Mouratoff GJ, Kaufman JE | title = Prodilidine Hydrochloride: A new moderately potent analgesic | journal = The American Journal of the Medical Sciences | volume = 247 | pages = 62–8 | date = January 1964 | pmid = 14106881 | doi = 10.1097/00000441-196401000-00009 | s2cid = 41209143 }}</ref>
+== See also ==
+* [[Profadol]]
 == References ==
+{{Reflist}}
-<references />
-{{opioids}}
+{{Opioidergics}}
 [[Category:Opioids]]
-[[Category:Propionates]]
+[[Category:Propionate esters]]
 [[Category:Pyrrolidines]]
-[[Category:Mu-opioid agonists]]
+[[Category:Mu-opioid receptor agonists]]