Proglumetacin: Difference between revisions

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+{{Short description|Non-steroidal anti-inflammatory drug}}
-{{drugbox
+{{Drugbox
-| Verifiedfields = changed
-| UNII_Ref = {{fdacite|changed|FDA}}
+| Watchedfields = changed
+| verifiedrevid = 443950501
-| UNII = FV919079LU
+| IUPAC_name = 3-<nowiki/>{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1''H''-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl ''N''<sup>2</sup>-benzoyl-''N,N''-dipropyl-α-glutaminate
-| verifiedrevid = 400862995
+| image = Proglumetacin.svg
-| IUPAC_name        = 3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1''H''-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl ''N''<sup>2</sup>-benzoyl-''N,N''-dipropyl-α-glutaminate
-|synonyms = <small>3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate</small>
+<!--Clinical data-->
-| image             = Proglumetacin.svg
+| tradename =
+| Drugs.com = {{drugs.com|international|proglumetacin}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism = [[Liver|Hepatic]]. Undergoes [[enterohepatic circulation|enterohepatic recirculation]]
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number = 57132-53-3
+| CAS_supplemental = {{CAS|59209-40-4}}
+| ATC_prefix = M01
+| ATC_suffix = AB14
+| PubChem = 4921
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
 | ChemSpiderID = 4752
+| ChEBI = 76263
-| InChI = 1/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)
+| UNII_Ref = {{fdacite|correct|FDA}}
-| InChIKey = PTXGHCGBYMQQIG-UHFFFAOYAO
+| UNII = FV919079LU
+<!--Chemical data-->
+| C=46 | H=58 | Cl=1 | N=5 | O=8
 | smiles = Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5
 | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
@@ Line 16: / Line 47: @@
 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
 | StdInChIKey = PTXGHCGBYMQQIG-UHFFFAOYSA-N
+| synonyms = <small>3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate</small>
-| CAS_number        = 57132-53-3
-| CAS_supplemental  = {{CAS|59209-40-4}} ([[maleate]])
-| ATC_prefix        = M01
-| ATC_suffix        = AB14
-| PubChem           = 4921
-| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| DrugBank          =
-| C=46|H=58|Cl=1|N=5|O=8
-| molecular_weight  = 844.43442 g/mol
-| bioavailability   =
-| protein_bound     =
-| metabolism        = [[Liver|Hepatic]]. Undergoes [[enterohepatic circulation|enterohepatic recirculation]]
-| elimination_half-life =
-| excretion         =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
-| pregnancy_category=
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_status      =
-| routes_of_administration =
 }}
-'''Proglumetacin''' (usually as the [[maleate]] salt, trade names '''Afloxan''', '''Protaxon''' and '''Proxil''') is a [[non-steroidal anti-inflammatory drug]]. It is [[drug metabolism|metabolized]] in the body to [[indometacin]] and [[proglumide]],<ref>{{cite journal |author=Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L |title=Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog |journal=Arzneimittel-Forschung |volume=37 |issue=6 |pages=698–702 |year=1987 |pmid=3663267 |doi=}}</ref> a drug with [[wikt:antisecretory|antisecretory]] effects that helps prevent injury to the stomach lining.
+'''Proglumetacin''' (usually as the [[maleate]] salt, trade names '''Afloxan''', '''Protaxon''' and '''Proxil''') is a [[nonsteroidal anti-inflammatory drug]] (NSAID). It is [[drug metabolism|metabolized]] in the body to [[indometacin]] and [[proglumide]],<ref>{{cite journal |vauthors=Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L |title=Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog |journal=Arzneimittel-Forschung |volume=37 |issue=6 |pages=698–702 |year=1987 |pmid=3663267 }}</ref> a drug with [[wikt:antisecretory|antisecretory]] effects that helps prevent injury to the stomach lining.
 ==References==
@@ Line 46: / Line 56: @@
 {{Anti-inflammatory and antirheumatic products}}
+{{Prostanoidergics}}
-{{NSAIDs}}
-[[Category:Non-steroidal anti-inflammatory drugs]]
+[[Category:Nonsteroidal anti-inflammatory drugs]]
 [[Category:Prodrugs]]
-[[Category:Indoles]]
+[[Category:Indole ethers at the benzene ring]]
-[[Category:Amides]]
-[[Category:Phenol ethers]]
 [[Category:Piperazines]]
 [[Category:Carboxylate esters]]
@@ Line 59: / Line 67: @@
 {{musculoskeletal-drug-stub}}
-[[es:Proglumetacina]]
-[[sr:Proglumetacin]]
-[[vi:Proglumetacin]]