S-17092: Difference between revisions

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| verifiedrevid = 407869477

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| image = S-17092_structure_corrected.PNG‎

| width = 240

| C = 23 | H = 29 | F = 1 | N = 2 | O = 2

| molecular_weight = 384.486 g/mol

| smiles = C5CCCN5C(=O)C1CC3CCCCC3N1C(=O)C2CC2c(cc4)ccc4F

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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->

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| legal_status = Investigational New Medicine

'''S-17092''' is a drug which acts as a selective [[enzyme inhibition|inhibitor]] of the enzyme [[Prolyl endopeptidase]].<ref>Barelli H, Petit A, Hirsch E, Wilk S, De Nanteuil G, Morain P, Checler F. S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase. ''Biochemical and Biophysical Research and Communications''. 1999 Apr 21;257(3):657-61. PMID 10208839</ref> This enzyme is involved in the metabolic breakdown of a number of [[neuropeptide]] [[neurotransmitter]]s in the brain,<ref>Bellemère G, Morain P, Vaudry H, Jégou S. Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. ''Journal of Neurochemistry''. 2003 Mar;84(5):919-29. {{DOI|10.1046/j.1471-4159.2003.01536.x}} PMID 12603817</ref><ref>Bellemère G, Vaudry H, Morain P, Jégou S. Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain. ''Journal of Neuroendocrinology''. 2005 May;17(5):306-13. PMID 15869566</ref> and so inhibiting the action of the enzyme increases the activity of these neuropeptides. This produces [[nootropic]] effects which make S-17092 a promising and novel treatment for neurodegenerative conditions such as [[Alzheimer's disease]] and [[Parkinson's disease]].<ref>Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, Boyer PA. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. ''CNS Drug Reviews''. 2002 Spring;8(1):31-52. PMID 12070525</ref><ref>Morain P, Boeijinga PH, Demazières A, De Nanteuil G, Luthringer R. Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers. ''Neuropsychobiology''. 2007;55(3-4):176-83. PMID 17700042</ref>

==See also==

==References==

{{Psychostimulants, agents used for ADHD and nootropics}}

[[Category:Enzyme inhibitors]]

[[Category:Amides]]