Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Zymosan: Difference between pages
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Saving copy of the {{chembox}} taken from revid 476539113 of page Zymosan for the Chem/Drugbox validation project (updated: 'CASNo'). |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid [{{fullurl:Zymosan|oldid=476539113}} 476539113] of page [[Zymosan]] with values updated to verified values.}} |
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| verifiedrevid = 477869701 |
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| ImageFile = Zymosan.png |
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| CASNo = 9010-72-4 |
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| CASNo = <!-- blanked - oldvalue: 9010-72-4 --> |
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|Section2={{Chembox Properties |
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| Formula = (C<sub>6</sub>H<sub>10</sub>O<sub>5</sub>)<sub>x</sub> |
| Formula = (C<sub>6</sub>H<sub>10</sub>O<sub>5</sub>)<sub>x</sub> |
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| MolarMass = Variable |
| MolarMass = Variable |
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|Section3={{Chembox Hazards |
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'''Zymosan''' is a [[beta-glucan]] with repeating [[glucose]] units connected by β-1,3-glycosidic linkages. It binds to [[TLR 2]] and Dectin-1 ([[CLEC7A]]). Zymosan is a ligand found on the surface of fungi, like yeast. <ref>{{cite journal |vauthors=Sato M, Sano H, Iwaki D, etal |title=Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A |journal=J. Immunol. |volume=171 |issue=1 |pages=417–25 |year=2003 |pmid=12817025 |doi=10.4049/jimmunol.171.1.417|doi-access=free }}</ref> |
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Zymosan is prepared from yeast [[Cell wall|cell walls]] and consists of [[protein]]-[[carbohydrate]] complexes. It is used to induce experimental sterile [[inflammation]]. In [[macrophages]], zymosan-induced responses include the induction of [[Inflammatory cytokine|proinflammatory cytokines]], [[arachidonate]] mobilization, [[protein phosphorylation]], and [[inositol phosphate]] formation. Zymosan A also raises [[cyclin D2]] levels, suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after [[galactosamine]] injection, suggesting that certain types of [[Parenchyma|nonparenchymal cells]] other than [[Kupffer cell|Kupffer cells]] are involved in zymosan action.<ref>[http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/Z4250 Zymosan A from Saccharomyces cerevisiae] Merck KGaA</ref> |
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==References== |
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{{Reflist}} |
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==External links== |
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* {{MeshName|Zymosan}} |
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{{Carbohydrates}} |
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[[Category:Polysaccharides]] |
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