Dynorphin A: Difference between revisions

| verifiedrevid = 428948268

| Reference=<ref>[https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=16130969 Dynorphin 1-13 - Compound Summary], [[PubChem]].</ref>

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| UNII = VFC23V742Z

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'''Dynorphin A''' is a [[dynorphin]], an [[endogenous]] [[opioid peptide]] that activates the [[κ-opioid receptor]].<ref name=":0">{{Cite journal |last1=Wang |first1=Yue |last2=Zhuang |first2=Youwen |last3=DiBerto |first3=Jeffrey F. |last4=Zhou |first4=X. Edward |last5=Schmitz |first5=Gavin P. |last6=Yuan |first6=Qingning |last7=Jain |first7=Manish K. |last8=Liu |first8=Weiyi |last9=Melcher |first9=Karsten |last10=Jiang |first10=Yi |last11=Roth |first11=Bryan L. |last12=Xu |first12=H. Eric |date=2023-01-12 |title=Structures of the entire human opioid receptor family |journal=Cell |language=en |volume=186 |issue=2 |pages=413–427.e17 |doi=10.1016/j.cell.2022.12.026|pmid=36638794 |s2cid=255750597 |doi-access=free }}</ref> Its [[amino acid sequence]] is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

'''Dynorphin A_1–8''' is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.<ref name="HMDB Dynorphin A 1-8">{{cite encyclopedia | title=Dynorphin A 1-8 | url=http://www.hmdb.ca/metabolites/HMDB0012933 | encyclopedia=HMDB Version&nbsp;4.0 | publisher=Human Metabolome Database | access-date=20 October 2017 | date=27 September 2017 }}</ref><ref name="IUPHAR - Dynorphin A-(1-8) - Biological activity">{{cite web | title=Dynorphin A-(1-8): Biological activity | url=http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=1621 | work= IUPHAR/BPS Guide to PHARMACOLOGY | publisher=International Union of Basic and Clinical Pharmacology | access-date= 20 October 2017 | quote = Principal endogenous agonists at κ receptor}}</ref> Dynorphin A_1–8 is an [[agonist]] at the mu-, kappa-, and delta-[[opioid receptor]]s;<ref name="IUPHAR - Dynorphin A-(1-8) - Biological activity" /> it has the highest binding affinity for the [[kappa-opioid receptor]].<ref name="IUPHAR - Dynorphin A-(1-8) - Biological activity" /> Structures of dynorphin A bound to the κ-opioid receptor have been reported.<ref name=":0" /><ref>{{Cite journal |last1=Chen |first1=Yuxiang |last2=Chen |first2=Bo |last3=Wu |first3=Tingting |last4=Zhou |first4=Fangfang |last5=Xu |first5=Fei |date=2022-08-05 |title=Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A |url=https://academic.oup.com/proteincell/advance-article/doi/10.1093/procel/pwac033/6656488 |journal=Protein & Cell |volume=14 |issue=6 |language=en |pages=464–468 |doi=10.1093/procel/pwac033 |pmid=37285260 |issn=1674-800X|pmc=10246719 }}</ref>

{{Reflist|2}}

{{Opioidergics}}

[[Category:Kappa-opioid receptor agonists]]

[[Category:Opioid peptides]]

{{organic-compound-stub}}