Tigemonam: Difference between revisions

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{{chembox

| Verifiedfields = changed

| Watchedfields = changed

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| verifiedrevid = 444385753

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| ImageFile=Tigemonam.svg

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| ImageSize=250px

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| IUPACName=2-<nowiki>[[</nowiki>1-(2-Amino-1,3-thiazol-4-yl)- 2-<nowiki>[[</nowiki>(3''S'')-2,2-dimethyl-4-oxo-1- sulfooxyazetidin-3-yl]amino]-2- oxoethylidene]amino]oxyacetic acid

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| OtherNames= Tigemen

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|Section1={{Chembox Identifiers

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 82H1LDS5D0

| CASNo_Ref = {{cascite|correct|??}}

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| verifiedrevid = ~~437163991~~

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| CASNo=102507-71-1

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|ImageFile=~~tigemonam~~.~~png~~

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| PubChem=9576769

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|ImageSize=~~200px~~

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| SMILES=CC1([C@@H](C(=O)N1OS(=O)(=O)O)NC(=O)/C(=N\OCC(=O)O)/C2=CSC(=N2)N)C

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|IUPACName=2-<nowiki>[[</nowiki>1-(2-Amino-1,3-thiazol-4-yl)- 2-<nowiki>[[</nowiki>(3''S'')-2,2-dimethyl-4-oxo-1- sulfooxyazetidin-3-yl]amino]-2- oxoethylidene]amino]oxyacetic acid

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

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|OtherNames=

| ChemSpiderID = 7851210

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|Section1={{Chembox Identifiers

| InChI = 1/C12H15N5O9S2/c1-12(2)8(10(21)17(12)26-28(22,23)24)15-9(20)7(16-25-3-6(18)19)5-4-27-11(13)14-5/h4,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)(H,22,23,24)/b16-7-/t8-/m1/s1

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| CASNo=102507-71-1

| InChIKey = VAMSVIZLXJOLHZ-QWFSEIHXBK

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| PubChem=9576769

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

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| SMILES=CC1([C@@H](C(=O)N1OS(=O)(=O)O)NC(=O)/C(=N\OCC(=O)O)/C2=CSC(=N2)N)C

| StdInChI = 1S/C12H15N5O9S2/c1-12(2)8(10(21)17(12)26-28(22,23)24)15-9(20)7(16-25-3-6(18)19)5-4-27-11(13)14-5/h4,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)(H,22,23,24)/b16-7-/t8-/m1/s1

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = VAMSVIZLXJOLHZ-QWFSEIHXSA-N

}}

|Section2={{Chembox Properties

| C=12|H=15|N=5|O=9|S=2

| Formula=C12H15N5O9S2

| Appearance=

| MolarMass=437.4056

| ~~Appearance~~=

| Density=

| ~~Density~~=

| MeltingPt=

| ~~MeltingPt~~=

| BoilingPt=

| ~~BoilingPt~~=

| Solubility=

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|Section3={{Chembox Hazards

| MainHazards=

| FlashPt=

| AutoignitionPt =

| Autoignition=

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'''Tigemonam''' is a [[monobactam]] antibiotic.<ref name="pmid3259122">{{cite journal |~~author~~=Fuchs PC, Jones RN, Barry AL |title=In vitro antimicrobial activity of tigemonam, a new orally administered monobactam |journal=Antimicrob. Agents Chemother. |volume=32 |issue=3 |pages=346–9 |~~year~~=1988 ~~|month=March~~ |pmid=3259122 |pmc=172173 |doi= ~~|url=http:/~~/aac.~~asm~~.~~org/cgi/pmidlookup?view~~=~~long&pmid=3259122~~}}</ref><ref name="pmid3279906">{{cite journal |~~author~~=Chin NX, Neu HC |title=Tigemonam, an oral monobactam |journal=Antimicrob. Agents Chemother. |volume=32 |issue=1 |pages=84–91 |~~year~~=1988 ~~|month=January~~ |pmid=3279906 |pmc=172104 |doi= ~~|url=http:/~~/aac.~~asm~~.~~org/cgi/pmidlookup?view~~=~~long&pmid=3279906~~}}</ref>

'''Tigemonam''' is a [[monobactam]] [[antibiotic]].<ref name="pmid3259122">{{cite journal |vauthors=Fuchs PC, Jones RN, Barry AL |title=In vitro antimicrobial activity of tigemonam, a new orally administered monobactam |journal=Antimicrob. Agents Chemother. |volume=32 |issue=3 |pages=346–9 |date=March 1988 |pmid=3259122 |pmc=172173 |doi= 10.1128/aac.32.3.346|url=}}</ref><ref name="pmid3279906">{{cite journal |vauthors=Chin NX, Neu HC |title=Tigemonam, an oral monobactam |journal=Antimicrob. Agents Chemother. |volume=32 |issue=1 |pages=84–91 |date=January 1988 |pmid=3279906 |pmc=172104 |doi= 10.1128/aac.32.1.84|url=}}</ref>

==References==

~~[[Category:Beta-lactam~~ antibiotics]]

[[Category:Monobactam antibiotics]]

[[Category:Thiazoles]]

[[Category:Azetidines]]

[[Category:Sulfonic acids]]

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[[pl:Tigemonam]]