Cinolazepam: Difference between revisions

{{Short description|Chemical compound}}

{{distinguish|cinazepam|clonazepam|camazepam}}

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| verifiedrevid = 447551787

| IUPAC_name = (''RS'')-3-[9-Chloro-6-(2-fluorophenyl)-4-hydroxy-3-oxo-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-2-yl]propanenitrile

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| chirality = [[Racemic mixture]]

| tradename = Gerodorm

| Drugs.com = {{drugs.com|parent|cinolazepam}}

| pregnancy_category =

| legal_US = Unscheduled

| bioavailability = 90–100%

| elimination_half-life = 3.8 hours<ref name=half-life>{{cite press release |author=<!--Staff writer(s); no by-line.--> |date=October 2018 |title=ZUSAMMENFASSUNG DER MERKMALE DES ARZNEIMITTELS |url=https://aspregister.basg.gv.at/document/servlet?action=show&zulnr=1-19288&type=DOTC_FACH_INFO |location=Austria |publisher=G.L. Pharma GmbH |agency=Bundesamt für Sicherheit im Gesundheitswesen |archive-url=https://web.archive.org/web/20190102113955/https://aspregister.basg.gv.at/document/servlet?action=show&zulnr=1-19288&type=DOTC_FACH_INFO |archive-date=2019-01-02 |access-date=2019-01-02 |version=(in [[Austrian German]])}}</ref>

| CAS_number_Ref = {{cascite|correct|??}}

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 2104926

| C=18 | H=13 | Cl=1 | F=1 | N=3 | O=2

| smiles = FC1=CC=CC=C1C2=NC(C(N(CCC#N)C3=C2C=C(C=C3)Cl)=O)O

|drug_name=|alt=|caption=|type=|MedlinePlus=|legal_status=|licence_EU=|pregnancy_AU=|pregnancy_US=|licence_US=}}

'''Cinolazepam'''<ref> US Patent 4388313 Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof</ref> (marketed under the brand name '''Gerodorm''')<ref name=Gerodorm>{{cite web|url=http://www.lannacher.ro/gerodorm.html |title=Gerodorm |access-date=17 August 2006 |author=Lannacher Romania |year=1999 |work=Produse Gerot inregistrate in Romania |language=ro |archive-url=https://web.archive.org/web/20061011022835/http://www.lannacher.ro/gerodorm.html |archive-date=11 October 2006 |url-status=dead }}</ref> is a drug which is a [[benzodiazepine]] derivative. It possesses [[anxiolytic]], [[anticonvulsant]], [[sedative]] and [[skeletal muscle relaxant]] properties.

Due to its strong sedative properties, it is primarily used as a [[hypnotic]].

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It was patented in 1978 and came into medical use in 1992.<ref name=Fis2006>{{cite book | vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=530 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA530 |language=en}}</ref> Cinolazepam is not approved for sale in the United States or Canada.

{{GABAAR PAMs}}

[[Category:Secondary alcohols]]

[[Category:Chloroarenes]]

[[Category:Fluoroarenes]]

[[Category:Lactams]]