Triflubazam: Difference between revisions

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Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or [[user talk:CheMoB
 
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{{Short description|Chemical compound}}
{{Drugbox
{{Use dmy dates|date=April 2023}}
⚫
| verifiedrevid = 447995497
{{Infobox drug
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| IUPAC_name = 1-methyl- 5-phenyl- 7-(trifluoromethyl)- 1''H''-1,5-benzodiazepine- 2,4(3''H'',5''H'')-dione
| Watchedfields = changed
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| verifiedrevid = 449589606
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| IUPAC_name = 1-methyl-5-phenyl-7-(trifluoromethyl)-1''H''-1,5-benzodiazepine-2,4(3''H'',5''H'')-dione
| image = Triflubazam.svg
| image = Triflubazam.svg
| width = 180
| width = 190


<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename =
| legal_status =
| legal_status =


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
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| metabolism =
| metabolism =
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 22365-40-8
| CAS_number = 22365-40-8
| ATC_prefix = none
| ATC_prefix =
| PubChem = 31157
| PubChem = 31157
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
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| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 80D8H0388T
| UNII = 80D8H0388T
| KEGG = D06231
| ChEMBL = 2107285


<!--Chemical data-->
<!--Chemical data-->
| C=17 | H=13 | F=3 | N=2 | O=2
| C=17 | H=13 | F=3 | N=2 | O=2
| smiles = FC(F)(C1=CC(N(C2=CC=CC=C2)C(CC(N3C)=O)=O)=C3C=C1)F
| molecular_weight = 334.29
| smiles = FC(F)(F)c3ccc1c(N(C(=O)CC(=O)N1C)c2ccccc2)c3
| InChI = 1/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3
| InChIKey = DMNPCIKBNDKNTO-UHFFFAOYAT
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3
| StdInChI = 1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3
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}}
}}


'''Triflubazam''' is a drug which is a 1,5-[[benzodiazepine]] derivative, related to [[clobazam]].<ref>{{cite web |url=http://www.psychotropics.dk/moleculeView/default.aspx?ID=1451&Catalogtype=A&ChapterID=1&Thissortorder=48 |title=triflubazam |author=Lundbeck Institute |authorlink=lundbeck |year=2003 |publisher=psychotropics.dk |accessdate=17th November 2010 }}</ref> It has [[sedative]] and [[anxiolytic]] effects, with a long half-life and duration of action.<ref>Itil TM, Akpinar S, Fink M: Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome. ''Current Therapeutic Research'' 1976; 19: 307-315</ref><ref>Csanalosi I, Pereira-Oran J, Case G, et al.: Triflubazam (ORF 8063), a new benzodiazepine in anxiety neurosis. ''Current Therapeutic Research'' 1977; 22: 166-171</ref><ref>Nicholson AN, Stone BM, Clarke CH. Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man. ''British Journal of Clinical Pharmacology''. 1977 Oct;4(5):567-72.</ref>
'''Triflubazam'''<ref>{{cite patent | country = US | number = 3660381 | title = 5-Aryl-1H-1,5-benzodiazepine-2,4-diones | inventor = Karl-Heinz Weber KH, Merz H, K Zeile, Giesemann R, Danneberg P | gdate = 2 May 1972 | assign1 = CH Boehringer Sohn AG and Co KG }}</ref> is a drug which is a 1,5-[[benzodiazepine]] derivative, related to [[clobazam]].<ref>{{cite web |url=http://www.psychotropics.dk/moleculeView/default.aspx?ID=1451&Catalogtype=A&ChapterID=1&Thissortorder=48 |title=triflubazam |author=Lundbeck Institute |author-link=lundbeck |year=2003 |publisher=psychotropics.dk |access-date=17 November 2010 }}</ref> It has [[sedative]] and [[anxiolytic]] effects, with a long half-life and duration of action.<ref name="pmid5248">{{cite journal | vauthors = Itil TM, Akpinar S, Fink M, Polvan N, Huque M, Sungurbey K | title = Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome | journal = Current Therapeutic Research, Clinical and Experimental | volume = 19 | issue = 3 | pages = 307–15 | date = March 1976 | pmid = 5248 }}</ref><ref>{{cite journal | vauthors = Csanalosi I, Pereira-Oran J, Case G, etal | title = Triflubazam (ORF 8063), a new benzodiazepine in anxiety neurosis. | journal = Current Therapeutic Research | date = 1977 | volume = 22 | pages = 166–171 }}</ref><ref name="pmid20917">{{cite journal | vauthors = Nicholson AN, Stone BM, Clarke CH | title = Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man | journal = British Journal of Clinical Pharmacology | volume = 4 | issue = 5 | pages = 567–72 | date = October 1977 | pmid = 20917 | pmc = 1429140 | doi = 10.1111/j.1365-2125.1977.tb00787.x }}</ref>


==See also==
==See also==
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*[[Clobazam]]
*[[Clobazam]]
*[[CP-1414S]]
*[[CP-1414S]]
*[[Triflunordazepam]]


==References==
==References==
{{Reflist}}
<references/>


{{Benzodiazepines}}
{{Benzodiazepines}}
{{GABAAR PAMs}}


[[Category:Benzodiazepines]]
[[Category:Benzodiazepines]]
[[Category:Organofluorides]]
[[Category:Lactams]]
[[Category:Lactams]]
[[Category:Trifluoromethyl compounds]]




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