L-368,899: Difference between revisions

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| molecular_weight = 554.260 g/mol

'''L-368,899''' is a drug used in scientific research which acts as a selective [[Antagonist (pharmacology)|antagonist]] of the [[oxytocin receptor]], with good selectivity over the related [[vasopressin receptor]]s.<ref name="pmid8126695">{{cite journal |author=Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE |title=1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor |journal=Journal of Medicinal Chemistry |volume=37 |issue=5 |pages=565–71 |year=1994 |month=March |pmid=8126695 |doi= 10.1021/jm00031a004|url=}}</ref> Unlike related drugs such as the peripherally selective [[L-371,257]], the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the [[limbic system]]. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.<ref name="pmid17583705">{{cite journal |author=Boccia ML, Goursaud AP, Bachevalier J, Anderson KD, Pedersen CA |title=Peripherally administered non-peptide oxytocin antagonist, L368,899, accumulates in limbic brain areas: a new pharmacological tool for the study of social motivation in non-human primates |journal=Hormones and Behavior |volume=52 |issue=3 |pages=344–51 |year=2007 |month=September |pmid=17583705 |pmc=2712625 |doi=10.1016/j.yhbeh.2007.05.009 |url=}}</ref><ref name="pmid20025881">{{cite journal |author=Smith AS, Agmo A, Birnie AK, French JA |title=Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata |journal=Hormones and Behavior |volume=57 |issue=2 |pages=255–62 |year=2010 |month=February |pmid=20025881 |pmc=2824532 |doi=10.1016/j.yhbeh.2009.12.004 |url=}}</ref>

== References ==

{{reflist}}

{{Neuropeptide agonists and antagonists}}

[[Category:Tocolytics]]

{{systemic-hormonal-drug-stub}}

[[sr:L-368,899]]