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  • Thumbnail for Aspartic protease
    Aspartic proteases (also "aspartyl proteases", "aspartic endopeptidases") are a catalytic type of protease enzymes that use an activated water molecule...
    10 KB (999 words) - 06:14, 23 February 2023
  • Thumbnail for HIV-1 protease
    HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential...
    20 KB (2,197 words) - 00:57, 13 January 2024
  • Thumbnail for Cathepsin
    (cysteine protease) Cathepsin D (aspartyl protease) Cathepsin E (aspartyl protease) Cathepsin F (cysteine proteinase) Cathepsin G (serine protease) Cathepsin...
    20 KB (2,371 words) - 22:28, 25 April 2024
  • Thumbnail for Cathepsin E
    as slow-moving proteinase, erythrocyte membrane aspartic proteinase, SMP, EMAP, non-pepsin proteinase, cathepsin D-like acid proteinase, cathepsin E-like...
    18 KB (2,278 words) - 03:10, 24 December 2023
  • Thumbnail for Cathepsin D
    that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light...
    22 KB (2,616 words) - 02:37, 10 March 2024
  • Thumbnail for NAPSA
    of the pepsin family. The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are...
    5 KB (654 words) - 03:52, 6 May 2024
  • Thumbnail for Cathepsin S
    Chronologically, action of cathepsin S follows two cleavages performed by aspartyl proteases. Cathepsin S cleaves the remaining fragment of Ii (IiP1) and...
    17 KB (2,262 words) - 22:29, 25 April 2024
  • Thumbnail for Proteolysis
    proteases and their inhibitors may also be involved in this disease, for example matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases...
    34 KB (4,225 words) - 03:34, 2 April 2024
  • Thumbnail for Pepsin A
    1038/319033a0. PMID 3941737. Fruton, J.S.; Brocklehurst, K. (1987). "Aspartyl proteinases". In Neuberger, A. (ed.). New Comprehensive Biochemistry: Hydrolytic...
    3 KB (298 words) - 15:18, 26 August 2023
  • Thumbnail for Bivalirudin
    Bivalirudin (category Direct thrombin inhibitors)
    indirect thrombin inhibitors, such as heparin. A short, synthetic peptide, it is a potent and highly specific inhibitor of thrombin that inhibits both circulating...
    28 KB (2,792 words) - 20:16, 23 April 2024
  • Thumbnail for EGF-like domain
    post-translational modification is unclear, but mice with a knockout of the aspartyl-β-hydroxylation enzyme show developmental defects. Proteins containing...
    25 KB (3,071 words) - 21:41, 10 September 2022