2,6-Dimethylpiperidine
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Names | |
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Preferred IUPAC name
2,6-Dimethylpiperidine | |
Other names
2,6-Lupetidine; nanofin; nanophyn
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.007.256 |
EC Number |
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PubChem CID
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RTECS number |
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C7H15N | |
Molar mass | 113.204 g·mol−1 |
Appearance | Colorless liquid |
Density | 0.84 g/mL |
Boiling point | 113.2 °C (235.8 °F; 386.3 K) |
Low | |
Solubility in other solvents | Most organic solvents |
Basicity (pKb) | ca. 10 |
Refractive index (nD)
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1.4394 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Flammable |
GHS labelling: | |
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Danger | |
H225, H314, H315, H319, H335 | |
P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501 | |
Flash point | 11 °C (52 °F; 284 K) |
Related compounds | |
Related compounds
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Piperidine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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2,6-Dimethylpiperidines are chemical compounds with the formula C5H8(CH3)2NH. Three stereoisomers exist: the achiral (R,S)-isomer and the chiral (R,R)/(S,S) enantiomeric pair. Dimethylpiperidines are derivatives of the heterocycle piperidine, wherein two hydrogen atoms are replaced by methyl groups.
The 2,6-dimethylpiperidines are prepared by reduction of 2,6-dimethylpyridine (2,6-lutidine). The achiral isomer is the predominant isomer produced in this reaction.
The 2,6-dimethylpiperidines are of interest for their conformational properties. The (R,S)-isomer exists largely in the chair conformation with equatorial methyl groups. The (R,R)/(S,S)-isomers are attractive chiral secondary amine building blocks.[1]
References
See also
Compound Summary 2,6-Dimethylpiperidine on National Library of Medicine National Center