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2E or II-E may refer to:
- 2nd meridian east, a longitude coordinate
- Apple IIe, a 1983 model in the Apple II series of personal computers
- Aptera 2e, the 2009 and first model in the Aptera 2 Series by Aptera Motors
- Oflag II-E, a prisoner of war camp in Germany
- 2nd arrondissement of Paris
- Transcription Factor II E
- Twice exceptional, an individual with special needs who is also gifted.
- A reference to data collected by the Einstein Observatory (version 2)
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