3-Hydroxyasparagine

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3-Hydroxyasparagine
3-Hydroxyasparagine.svg
Names
IUPAC name
(2S)-2,4-Diamino-3-hydroxy-4-oxobutanoic acid; Hyn
Other names
β-Hydroxyasparagine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
DrugBank
KEGG
UNII
  • InChI=1S/C4H8N2O4/c5-1(4(9)10)2(7)3(6)8/h1-2,7H,5H2,(H2,6,8)(H,9,10)/t1-,2?/m0/s1
    Key: VQTLPSCRBFYDNX-PIKHSQJKSA-N
  • [C@H](C(C(=O)N)O)(C(=O)O)N
Properties
C4H8N2O4
Molar mass 148.118 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

3-Hydroxyasparagine also known as β-hydroxyasparagine (beta-hydroxyasparagine) is a modified asparagine amino acid. It appears in posttranslational modification of cbEGF-like domains which can occur in humans and other Eukaryotes. The amino acid code used for this is Hyn. The modified amino acid residue is found in fibrillin-1.[1] This amino acid is also found in urine.[2]

References[edit]

  1. ^ Glanville, RW; Qian, RQ; McClure, DW; Maslen, CL (28 October 1994). "Calcium binding, hydroxylation, and glycosylation of the precursor epidermal growth factor-like domains of fibrillin-1, the Marfan gene protein". The Journal of Biological Chemistry. 269 (43): 26630–4. doi:10.1016/S0021-9258(18)47065-2. PMID 7929395.
  2. ^ Barrett, Graham (2012). Chemistry and Biochemistry of the Amino Acids. Springer Science & Business Media. p. 80. ISBN 9789400948327.