3D model (JSmol)
|Molar mass||g·mol−1 127.103|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
5-Hydroxycytosine is an oxidized form of cytosine that is associated with an increased frequency of C to T transition mutations, with some C to G transversions. It does not distort the DNA molecule and is readily bypassed by replicative DNA polymerases.
It has been shown in vitro to miscode for adenine.
- Zahn KE; Averill A; Wallace SS; Doublié S (2011). "The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site". Biochemistry. 50 (47): 10350–10358. doi:10.1021/bi201219s. PMC 3280588. PMID 22026756.
- Helmut Greim; Richard J. Albertini (2012). The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens. Royal Society of Chemistry. p. 119. Retrieved July 20, 2015.