8-Hydroxyguanosine
Appearance
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Names | |
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IUPAC name
2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3,7-dihydropurine-6,8-dione
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Other names
8-Oxoguanosine
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.162.784 |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C10H13N5O6 | |
Molar mass | 299.24 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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8-Hydroxyguanosine is a nucleoside which is an oxidative derivative of guanosine. Measurement of the levels of 8-hydroxyguanosine is used as a biomarker of oxidative stress.[1]
See also
References
- ^ Cattley RC, Glover SE (1993). "Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization". Carcinogenesis. 14 (12): 2495–2499. doi:10.1093/carcin/14.12.2495. PMID 8269617.