8-Oxo-2'-deoxyguanosine

8-Oxo-2'-deoxyguanosine
Names
	IUPAC name 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
	Other names 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 7,8-Dihydro-8-oxodeoxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8-Oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 8-Oxo-dG
Identifiers
CAS Number	88847-89-6;
3D model (JSmol)	Interactive image; Interactive image;
ChEBI	CHEBI:40304;
ChemSpider	66049 ;
PubChem CID	73318;
CompTox Dashboard (EPA)	DTXSID60904338 ;
	InChI InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1 Key: HCAJQHYUCKICQH-VPENINKCSA-N ; InChI=1/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1 Key: HCAJQHYUCKICQH-VPENINKCBS;
	SMILES C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O; C1[C@@H]([C@H](O[C@H]1n2c3c(c(=O)nc([nH]3)N)[nH]c2=O)CO)O;
Properties
Chemical formula	C10H13N5O5
Molar mass	283.24 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine. 8-oxo-dG is one of the major products of DNA oxidation.^[1] Concentrations of 8-oxo-dG within a cell are a measurement of oxidative stress.

References

^ Nadja C. de Souza-Pinto, Lars Eide, Barbara A. Hogue, Tanja Thybo, Tinna Stevnsner, Erling Seeberg, Arne Klungland, and Vilhelm A. Bohr (July 2001). "Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice". Cancer Research. 61 (14): 5378–5381. PMID 11454679.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[1] Nadja C. de Souza-Pinto, Lars Eide, Barbara A. Hogue, Tanja Thybo, Tinna Stevnsner, Erling Seeberg, Arne Klungland, and Vilhelm A. Bohr (July 2001). "Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice". Cancer Research. 61 (14): 5378–5381. PMID 11454679.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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See also

References