Sodium glycerophosphate
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| Trade names | Glycophos |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | Intravenous infusion |
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| Chemical and physical data | |
| Formula | C3H7Na2O6P |
| Molar mass | 216.036 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 98 to 100 °C (208 to 212 °F) |
| Solubility in water | very soluble |
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Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate.[1][2] It is administered via intravenous infusion.[1][2]
Sodium glycerophosphate is an organic phosphate salt.[1][2]
It was approved for medical use in Australia in November 2019.[3][1][4]
It is an unapproved medication in the United States that was used as a substitute during a drug shortage.[2]
Chemistry
Ṯhe substance is a mixture of disodium glycerol 1- and 2-phosphates, which have different amounts of water of crystallization; the total amount is 5+1⁄2 H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at 98 to 100 °C (208 to 212 °F) and decomposes at 130 °C (266 °F). Aqueous solutions have a pH of about 9.5.[5]
References
- ^ a b c d "ARTG Entry:312021 Glycophos Product Information" (PDF). Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
- ^ a b c d "Glycophos- sodium glycolate injection, solution". DailyMed. 16 January 2019. Retrieved 23 August 2020.
- ^ "Glycophos Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
- ^ "Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule". Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
- ^ Hagers Handbuch der pharmazeutischen Praxis (in German). Vol. VI.A (4th ed.). Springer. 15 August 1977. pp. 91–92. ISBN 3-540-05123-6.
Further reading
- "Australian Public Assessment Report for Sodium glycerophosphate (as hydrate)" (PDF). Therapeutic Goods Administration (TGA).
External links
- "Sodium glycerophosphate anhydrous". Drug Information Portal. U.S. National Library of Medicine.
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