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Mathias Uhlén

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Mathias Uhlén (born May 1954) is a Swedish biologist, biotechnologist, and Professor of Microbiology at Royal Institute of Technology (KTH), Stockholm.[1] His research interests cover antibody engineering, proteomics and precision medicine.[1]

Life

In 1984 Uhlén was promoted for PhD at the Royal Institute of Technology (KTH) in Stockholm. After being employed at the European Molecular Biology Laboratory in Heidelberg, Germany, he became professor at KTH in 1988. His research has led to more than 650 publications, 63,000 citations.[2]

In 2003, as part of an international project to map the complete human proteome and transcriptome system, the Human Protein Atlas project was created and launched. Dr Uhlén is Program Director of the project. There are six additional projects within the primary project.

  • The Tissue Atlas[3] is a Swedish project to provide expression profiles of human genes both on the mRNA and protein level, within the body.
  • The Cell Atlas[4] provides high-resolution insights into the spatial distribution of proteins within cells.
  • The Pathology Atlas[5] showing how cancer patient survival is tied to RNA and protein levels. The project contains mRNA and protein expression data for the most common forms of human cancer.
  • The Blood Atlas[6] showing the expression of proteins in human immune cells and also mapping the proteins in human blood
  • The Brain Atlas[7] showing the proteins expressed in the different parts of human, pig and mouse brains.
  • The Single Cell Type Atlas shows single cell RNA sequencing (scRNAseq) data from 13 different human tissues, together with immunohistochemically stained tissue sections visualizing the corresponding spatial protein expression patterns.

Awards and Accolades

He is member of the

He is the President of the European Federation of Biotechnology. From 2010-2015, he was the founding Director of the Science for Life Laboratory (SciLifeLab) which is a national center for molecular bioscience.

References

  1. ^ a b "Mathias Uhlén". School of Engineering Sciences in Chemistry, Biotechnology and Health.
  2. ^ Mathias Uhlén publications indexed by Google Scholar
  3. ^ Uhlén M, et al. (2015). "Proteomics. Tissue-based map of the human proteome". Science. 347 (6220): 1260419. doi:10.1126/science.1260419. PMID 25613900. S2CID 802377.
  4. ^ Thul PJ, et al. (2017). "A subcellular map of the human proteome". Science. 356 (6340): eaal3321. doi:10.1126/science.aal3321. PMID 28495876. S2CID 10744558.
  5. ^ Uhlen M, et al. (2017). "A pathology atlas of the human cancer transcriptome". Science. 357 (6352): eaan2507. doi:10.1126/science.aan2507. PMID 28818916. S2CID 206659235.
  6. ^ Uhlen, M; et al. (2019). "A genome-wide transcriptomic analysis of protein-coding genes in human blood cells". Science. 366 (6472): eaax9198. doi:10.1126/science.aax9198. PMID 31857451. S2CID 209424418.
  7. ^ Sjöstedt, E; et al. (2020). "An atlas of the protein-coding genes in the human, pig, and mouse brain". Science. 367 (6482): eaay5947. doi:10.1126/science.aay5947. PMID 32139519. S2CID 212560645.
  8. ^ "2013 Annual Report" (pdf). National Academy of Engineering. NAE. 2013. Retrieved 17 January 2018.
  9. ^ "Mathias Uhlén". The Royal Swedish Academy of Sciences. The Royal Swedish Academy of Sciences. Retrieved 17 January 2018.
  10. ^ "Mathias Uhlén". EMBO People directory. Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH. Retrieved 17 January 2018.
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