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Eberhard Fetz

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Eberhard Erich Fetz
Born (1940-02-05) February 5, 1940 (age 84)
Zwenkau, Germany
CitizenshipAmerican
Occupation(s)Neuroscientist, academic and researcher
AwardsSloan Research Fellow
Humboldt Research Award
New York Academy of Sciences and Aspen Brain Forum First Prize in Neurotechnology
Fellow, AAAS
Academic background
EducationB.S., Physics
Ph.D., Physics
Alma materRensselaer Polytechnic Institute
Massachusetts Institute of Technology
ThesisPyramidal Tract Effects on Spinal Cord Interneurons.
Doctoral advisorPatrick David Wall
Academic work
InstitutionsUniversity of Washington

Eberhard Erich Fetz is an American neuroscientist, academic and researcher. He is a Professor of Physiology and Biophysics and DXARTS at the University of Washington.[1]

Fetz has authored over 160 papers on experimental neuroscience, brain-computer interfaces, and neural networks.[2] His research focuses on the neural control of limb movement in primates. He pioneered the recording of cortical and spinal neurons in behaving monkeys and the applications of bidirectional brain-computer interfaces.[3]

In 2020, Fetz was elected as a Fellow of the American Association for the Advancement of Science in Neuroscience.[4]

Education

Fetz received his B.S. in Physics from Rensselaer Polytechnic Institute in 1961 and his Doctoral degree in Physics from the Massachusetts Institute of Technology in 1966. He completed his Postdoctoral Training in Neuroscience at the Massachusetts Institute of Technology and University of Washington School of Medicine.[1]

Career

Fetz joined University of Washington School of Medicine as an Assistant Professor in 1969 and was promoted to Associate Professor in 1975. In 1980, he was promoted to Professor of Physiology and Biophysics, and in 2019 he was appointed as Professor of DXARTS at the University.[1]

From 1999 till 2005, he served as Associate Director for Neuroscience and was appointed as Head of the Neuroscience Division for a second time in 2012.[1]

Research

Fetz has worked on experimental neuroscience, brain-computer interfaces, and neural networks. His research includes studies on monkeys’ ability to volitionally control the activity of motor cortex cells and muscles with biofeedback, neural mechanisms of a primate model of focal epilepsy, the functional organization of premotor cells controlling forearm muscles and synaptic interactions between neurons. His later research developed an autonomous head-fixed bidirectional brain-computer interface that induced synaptic plasticity.[2]

Volitional control of motor cortex cells and muscles with biofeedback

Fetz studied the relation between motor cortex cells and forelimb muscles in behaving monkeys. He first investigated these relations by training monkeys to volitionally control the activity of brain cells and muscles with biofeedback.[5][6] The results demonstrated an unexpected degree of flexibility in quickly generating different rewarded response patterns, including dissociating the activity of motor cortex cells and correlated muscles when the monkeys were rewarded for such dissociation.[7] Feedback about the degree to which neural activity met criteria for reinforcement was provided through movement of a meter arm, and Fetz's studies were the first to demonstrate direct control of an external device through volitional modulation of brain cell activity, the precursor of present-day brain=computer interfaces.[8][9]

Functional connections in motor system

Fetz's research developed ways to document both the normal activity and the output connectivity of premotor cells in behaving monkeys.[10] Starting with corticomotoneuronal (CM) cells, he introduced the technique of spike-triggered averaging of muscle activity to document post-spike effects of premotor cells on motoneurons.[11]

He showed that motor cortex cells with correlational linkages to muscles affected multiple synergistic muscles[12] and causally contributed to generating muscle force. CM cells fired with specific movements involving their muscle field. In contrast, spinal cord premotor interneurons had smaller muscle fields and were active through broader ranges of movement.[13]

Activity of spinal cord interneurons in behaving monkeys

Fetz's lab was the first to document the activity of cervical spinal cord interneurons in behaving monkeys. He studied the post-spike effects of premotor neurons on forelimb muscles[14] and related their activity during controlled movements to their connectivity.[15] When monkeys performed an instructed delay task, many spinal interneurons were related to preparation for the cued movement before it was executed.[16]

Fetz and colleagues found that peripheral input to spinal cord is modulated by presynaptic inhibition of afferent sensory fibers, beginning prior to active movement.[17] His work provided the first evidence for the functional roles of primate cervical spinal cord interneurons in performing active hand movements.[13]

Synaptic interactions between neurons

Fetz's work has explained the synaptic interactions between cortical neurons using spike-triggered averages of intracellulary recorded membrane potentials[18] and cross-correlation of pairs of cells related to hand movement.[19] He documented the relationship between these two measures by determining the effects that excitatory postsynaptic potentials had on the firing rate of spinal motoneurons.[20] In primate motor cortex spike-triggered averages of membrane potentials exhibit features representing post-spike excitatory and inhibitory unitary potentials as well as synchrony effects of population activity.[18] He also investigated periodic synchronization in motor cortex through widespread oscillatory activity in neurons and field potentials.[21]

Bidirectional interactions between the brain and implantable computers

Fetz has also conducted research on closed-loop interactions between the brain and implantable computers.[22] He investigated the consequences of direct connections produced by an autonomous head-fixed bidirectional brain-computer interface [BBCI].[23]

Fetz studied the applications of BBCI to bridging impaired biological connections, including cortically controlled electrical stimulation of paralyzed forearm muscles[24] and cortically controlled intra-spinal stimulation.[25] He found several applications of the closed-loop BBCI in producing Hebbian plasticity between cortical sites, through stimulation triggered from action potentials of cells[22] or from phases of cortical beta oscillations[26] recorded at neighboring sites, or from EMG activity of muscles.[27] He and colleagues also strengthened cortico-spinal connections by cortically triggered intra-spinal stimulation, demonstrating in vivo effects of spike-timing dependent plasticity.[28] A third application of the closed-loop BBCI was to deliver stimulation at an intracranial reward site contingent on neural activity, thereby operantly training monkeys to control neural activity during free behavior.[29]

Awards/honors

  • 1970-1975 - NINDS Teacher-Investigator Award, National Institute of Neurological Disorders and Stroke
  • 1972-1974 - Sloan Research Fellow[30]
  • 1977-1978 - Josiah Macy Faculty Scholar Award
  • 1985-1986 - NSF US-Japan Cooperative Science Program Award
  • 2004-2005 - Fellow, Wissenschaftskolleg zu Berlin[31]
  • 2008-2015 - Associate, Neurosciences Research Program
  • 2009-2012 - Contributing member, Faculty of 1000
  • 2010-2011 - Humboldt Research Award[32]
  • 2010 - New York Academy of Sciences and Aspen Brain Forum first Prize in Neurotechnology[33]
  • 2020 – Elected Fellow of American Association for the Advancement of Science[4]

Bibliography

Books

  • Closing the Loop Around Neural Systems (2014) ISBN 9782889193561

Selected articles

  • Fetz, E.E. Are movement parameters recognizably coded in the activity of single neurons? Behavioral and Brain Sciences, 15: 679–690, 1992.[34]
  • Fetz, E.E. Toyama. K. and Smith, W. Synaptic interactions between cortical neurons, in CEREBRAL CORTEX, VOL IX ALTERED CORTICAL STATES, A. Peters and E. G. Jones, eds. Plenum Press, New York, 1-47, 1991.[34]
  • Fetz, E.E. Dynamic recurrent neural network models of sensorimotor behavior, in THE NEUROBIOLOGY OF NEURAL NETWORKS, Daniel Gardner, Ed. MIT Press, Cambridge MA, pp 165 – 190, 1993.[34]
  • Cheney, P.D. and Fetz, E.E. Functional classes of primate corticomotoneuronal cells and their relation to active force. Journal of Neurophysiology 44:773-791, 1980.[34]
  • Fetz, E.E. Artistic explorations of the brain, Frontiers in Human Neuroscience, 6:1-4, 2012[34]

References

  1. ^ a b c d "Faculty". Physiology and Biophysics.
  2. ^ a b "Eberhard E Fetz". scholar.google.com.
  3. ^ Stuart, Douglas G.; Brownstone, Robert M. (August 29, 2011). "The beginning of intracellular recording in spinal neurons: Facts, reflections, and speculations". Brain Research. 1409: 62–92. doi:10.1016/j.brainres.2011.06.007. PMC 5061568. PMID 21782158.
  4. ^ a b "2020 Fellows | American Association for the Advancement of Science". www.aaas.org.
  5. ^ Fetz, E. E. (February 28, 1969). "Operant Conditioning of Cortical Unit Activity". Science. 163 (3870): 955–958. Bibcode:1969Sci...163..955F. doi:10.1126/science.163.3870.955. PMID 4974291. S2CID 45427819.
  6. ^ Fetz, E E; Baker, M A (March 1, 1973). "Operantly conditioned patterns on precentral unit activity and correlated responses in adjacent cells and contralateral muscles". Journal of Neurophysiology. 36 (2): 179–204. doi:10.1152/jn.1973.36.2.179. PMID 4196269 – via journals.physiology.org (Atypon).
  7. ^ Fetz, E. E.; Finocchio, D. V. (September 1, 1975). "Correlations between activity of motor cortex cells and arm muscles during operantly conditioned response patterns". Experimental Brain Research. 23 (3): 217–240. doi:10.1007/BF00239736. PMID 810359. S2CID 23093887 – via Springer Link.
  8. ^ Fetz, Eberhard E. (January 8, 2007). "Volitional control of neural activity: implications for brain–computer interfaces". The Journal of Physiology. 579 (3): 571–579. doi:10.1113/jphysiol.2006.127142. PMC 2151376. PMID 17234689 – via Wiley Online Library.
  9. ^ "The man who helped launch brain-computer interfaces in 1969 has not finished yet".
  10. ^ "Neural mechanisms underlying corticospinal and rubrospinal control of limb movements" (PDF).
  11. ^ Fetz, E. E.; Cheney, P. D. (October 1, 1980). "Postspike facilitation of forelimb muscle activity by primate corticomotoneuronal cells". Journal of Neurophysiology. 44 (4): 751–772. doi:10.1152/jn.1980.44.4.751. PMID 6253604 – via journals.physiology.org (Atypon).
  12. ^ Cheney, P. D.; Fetz, E. E. (March 1, 1985). "Comparable patterns of muscle facilitation evoked by individual corticomotoneuronal (CM) cells and by single intracortical microstimuli in primates: evidence for functional groups of CM cells". Journal of Neurophysiology. 53 (3): 786–804. doi:10.1152/jn.1985.53.3.786. PMID 2984354 – via journals.physiology.org (Atypon).
  13. ^ a b Fetz, E. E; Perlmutter, S. I; Prut, Y; Seki, K; Votaw, S (October 1, 2002). "Roles of primate spinal interneurons in preparation and execution of voluntary hand movement". Brain Research Reviews. 40 (1): 53–65. doi:10.1016/S0165-0173(02)00188-1. PMID 12589906. S2CID 18895816 – via ScienceDirect.
  14. ^ Perlmutter, S. I.; Maier, M. A.; Fetz, E. E. (November 8, 1998). "Activity of spinal interneurons and their effects on forearm muscles during voluntary wrist movements in the monkey". Journal of Neurophysiology. 80 (5): 2475–2494. doi:10.1152/jn.1998.80.5.2475. PMID 9819257 – via PubMed.
  15. ^ Maier, Marc A.; Perlmutter, Steve I.; Fetz, Eberhard E. (November 1, 1998). "Response Patterns and Force Relations of Monkey Spinal Interneurons During Active Wrist Movement". Journal of Neurophysiology. 80 (5): 2495–2513. doi:10.1152/jn.1998.80.5.2495. PMID 9819258 – via journals.physiology.org (Atypon).
  16. ^ Prut, Yifat; Fetz, Eberhard E. (October 8, 1999). "Primate spinal interneurons show pre-movement instructed delay activity". Nature. 401 (6753): 590–594. Bibcode:1999Natur.401..590P. doi:10.1038/44145. PMID 10524626. S2CID 4324791 – via www.nature.com.
  17. ^ Seki, Kazuhiko; Perlmutter, Steve I.; Fetz, Eberhard E. (December 8, 2003). "Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement". Nature Neuroscience. 6 (12): 1309–1316. doi:10.1038/nn1154. PMID 14625555. S2CID 6105272 – via www.nature.com.
  18. ^ a b Matsumura, M.; Chen, D.; Sawaguchi, T.; Kubota, K.; Fetz, E. E. (December 1, 1996). "Synaptic interactions between primate precentral cortex neurons revealed by spike-triggered averaging of intracellular membrane potentials in vivo". The Journal of Neuroscience. 16 (23): 7757–7767. doi:10.1523/JNEUROSCI.16-23-07757.1996. PMC 6579078. PMID 8922431 – via PubMed.
  19. ^ Smith, W. S.; Fetz, E. E. (August 8, 2009). "Synaptic Interactions Between Forelimb-Related Motor Cortex Neurons in Behaving Primates". Journal of Neurophysiology. 102 (2): 1026–1039. doi:10.1152/jn.91051.2008. PMC 2724363. PMID 19439672.
  20. ^ Cope, T C; Fetz, E E; Matsumura, M (September 8, 1987). "Cross-correlation assessment of synaptic strength of single Ia fibre connections with triceps surae motoneurones in cats". The Journal of Physiology. 390: 161–188. doi:10.1113/jphysiol.1987.sp016692. PMC 1192172. PMID 3443932.
  21. ^ Murthy, V. N.; Fetz, E. E. (December 8, 1996). "Synchronization of neurons during local field potential oscillations in sensorimotor cortex of awake monkeys". Journal of Neurophysiology. 76 (6): 3968–3982. doi:10.1152/jn.1996.76.6.3968. PMID 8985893 – via PubMed.
  22. ^ a b Jackson, Andrew; Mavoori, Jaideep; Fetz, Eberhard E. (November 8, 2006). "Long-term motor cortex plasticity induced by an electronic neural implant". Nature. 444 (7115): 56–60. Bibcode:2006Natur.444...56J. doi:10.1038/nature05226. PMID 17057705. S2CID 4380207 – via www.nature.com.
  23. ^ Zanos, S.; Richardson, A. G.; Shupe, L.; Miles, F. P.; Fetz, E. E. (August 8, 2011). "The Neurochip-2: An Autonomous Head-Fixed Computer for Recording and Stimulating in Freely Behaving Monkeys". IEEE Transactions on Neural Systems and Rehabilitation Engineering. 19 (4): 427–435. doi:10.1109/TNSRE.2011.2158007. PMC 3159515. PMID 21632309 – via IEEE Xplore.
  24. ^ Moritz, Chet T.; Perlmutter, Steve I.; Fetz, Eberhard E. (December 8, 2008). "Direct control of paralysed muscles by cortical neurons". Nature. 456 (7222): 639–642. Bibcode:2008Natur.456..639M. doi:10.1038/nature07418. PMC 3159518. PMID 18923392 – via www.nature.com.
  25. ^ Nishimura, Yukio; Perlmutter, Steve I.; Fetz, Eberhard E. (January 8, 2013). "Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury". Frontiers in Neural Circuits. 7: 57. doi:10.3389/fncir.2013.00057. PMC 3622884. PMID 23596396 – via PubMed.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  26. ^ Zanos, Stavros; Rembado, Irene; Chen, Daofen; Fetz, Eberhard E. (August 20, 2018). "Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys". Current Biology. 28 (16): 2515–2526.e4. doi:10.1016/j.cub.2018.07.009. PMC 6108550. PMID 30100342 – via PubMed.
  27. ^ Lucas, Timothy H.; Fetz, Eberhard E. (March 20, 2013). "Myo-Cortical Crossed Feedback Reorganizes Primate Motor Cortex Output". Journal of Neuroscience. 33 (12): 5261–5274. doi:10.1523/JNEUROSCI.4683-12.2013. PMC 3684433. PMID 23516291.
  28. ^ Nishimura, Yukio; Perlmutter, Steve I.; Eaton, Ryan W.; Fetz, Eberhard E. (December 4, 2013). "Spike-Timing-Dependent Plasticity in Primate Corticospinal Connections Induced during Free Behavior". Neuron. 80 (5): 1301–1309. doi:10.1016/j.neuron.2013.08.028. PMC 4079851. PMID 24210907.
  29. ^ Eaton, Ryan W.; Libey, Tyler; Fetz, Eberhard E. (March 1, 2017). "Operant conditioning of neural activity in freely behaving monkeys with intracranial reinforcement". Journal of Neurophysiology. 117 (3): 1112–1125. doi:10.1152/jn.00423.2016. PMC 5340878. PMID 28031396 – via PubMed.
  30. ^ "Past Fellows". sloan.org.
  31. ^ "Wissenschaftskolleg zu Berlin: Eberhard E. Fetz, Ph.D." Eberhard E. Fetz, Ph.D.
  32. ^ "Eb Fetz named Alexander von Humboldt Fellow". Physiology and Biophysics.
  33. ^ "Winners of the Aspen Brain Forum Prize in Neurotechnology Announced".
  34. ^ a b c d e "Fetz Lab".
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