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Gp100:209-217(210M)

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Gp100:209-217(210M) is a synthetic peptide cancer vaccine consisting of amino acid residues 209 through 217 of the glycoprotein 100 (gp100) melanoma antigen, with a methionine substitution at position 210.[1] It is often referred to as the gp100 cancer vaccine which can also include other peptides based on gp100 (for example gp100:280-288(288V)[2][3]).

Clinical trials

It gave good results in a trial for advanced melanoma when used in combination with interleukin-2.[4]

Another trial against Ipilimumab in advanced melanoma suggested Ipilimumab may be better than the gp100 vaccine alone.[5]

References

  1. ^ http://www.cancer.gov/drugdictionary/?CdrID=476335 [bare URL]
  2. ^ http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=492712 [bare URL]
  3. ^ "Re-induction with ipilimumab, gp100 peptide vaccine, or a combination of both from a phase III, randomized, double-blind, multicenter study of previously treated patients with unresectable stage III or IV melanoma". 2010.
  4. ^ "Vaccine shows promise in advanced melanoma -study". Reuters. 30 May 2009.
  5. ^ "BMS' Ipilimumab Proves Itself in Metastatic Melanoma Patients". 7 June 2010.


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