Acidic leucine-rich nuclear phosphoprotein 32 family member C is a protein that in humans is encoded by the ANP32Cgene.[2][3][4]
Function
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.[4]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR (March 1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nature Medicine. 5 (3): 275–9. doi:10.1038/6488. PMID10086381. S2CID24559649.
^Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR (July 1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". The Journal of Biological Chemistry. 274 (29): 20053–5. doi:10.1074/jbc.274.29.20053. PMID10400610.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J (February 2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A". Nature Immunology. 4 (2): 145–53. doi:10.1038/ni885. PMID12524539. S2CID29433133.
Kadkol SS, El Naga GA, Brody JR, Bai J, Gusev Y, Dooley WC, Pasternack GR (July 2001). "Expression of pp32 gene family members in breast cancer". Breast Cancer Research and Treatment. 68 (1): 65–73. doi:10.1023/A:1017919507109. PMID11678310. S2CID11915912.
