CFHR3

CFHR3
Identifiers
Aliases	CFHR3, CFHL3, DOWN16, FHR-3, FHR3, HLF4, complement factor H related 3
External IDs	OMIM: 605336; HomoloGene: 137347; GeneCards: CFHR3; OMA:CFHR3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	196,795,407 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; epithelium of colon; ; left coronary artery; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; tibial nerve; ; Descending thoracic aorta; ; right auricle;
	n/a
	More reference expression data
	More reference expression data
Orthologs
	10878
	n/a
	ENSG00000116785
	n/a
	Q02985
	n/a
	NM_001166624; NM_021023
	n/a
	NP_001160096; NP_066303
	n/a
	Wikidata
View/Edit Human

Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116785 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Skerka C, Kuhn S, Gunther K, Lingelbach K, Zipfel PF (Mar 1993). "A novel short consensus repeat-containing molecule is related to human complement factor H". J Biol Chem. 268 (4): 2904–8. doi:10.1016/S0021-9258(18)53859-X. PMID 8428964.
^ Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.
^ "Entrez Gene: CFHR3 complement factor H-related 3".

Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. doi:10.1016/S0014-5793(99)01554-9. PMID 10622723.
Male DA, Ormsby RJ, Ranganathan S, et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes". Mol. Immunol. 37 (1–2): 41–52. doi:10.1016/S0161-5890(00)00024-9. PMID 10781834.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Zipfel PF, Edey M, Heinen S, et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome". PLOS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMC 1828695. PMID 17367211.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
OMIM entries on Atypical Hemolytic-Uremic Syndrome
Human CFHR3 genome location and CFHR3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116785 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8428964-3] Skerka C, Kuhn S, Gunther K, Lingelbach K, Zipfel PF (Mar 1993). "A novel short consensus repeat-containing molecule is related to human complement factor H". J Biol Chem. 268 (4): 2904–8. doi:10.1016/S0021-9258(18)53859-X. PMID 8428964.

[pmid10380701-4] Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701. S2CID 31776506.

[entrez-5] "Entrez Gene: CFHR3 complement factor H-related 3".

[1]

[2]

[3]

[4]

[5]

References

Further reading

External links