Saturation (genetic)
Genetic saturation is the result of multiple substitutions at the same site in a sequence, or identical substitutions in a different sequence, such that the apparent sequence divergence rate is lower than the actual divergence that has occurred.[1] In phylogenetics, saturation effects result in long branch attraction, where the most distant lineages have misleadingly short branch lengths. It also decreases phylogenetic information contained in the sequences.[2]
Genetic saturation occurs most rapidly on fast-evolving sequences, such as the hypervariable region of mitochondrial DNA, or in Short tandem repeats such as on the Y-chromosome.[3][4]
See also
References
- ^ Philippe H, Brinkmann H, Lavrov DV, Littlewood DT, Manuel M, Wörheide G, Baurain D (March 2011). "Resolving difficult phylogenetic questions: why more sequences are not enough". PLOS Biology. 9 (3): e1000602. doi:10.1371/journal.pbio.1000602. PMC 3057953. PMID 21423652.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Abylgazieva NA (2003-01-01). "[Case of "renal diabetes"]". Zdravookhranenie Kirgizii. 26 (3): 49–51. doi:10.1016/S1055-7903(02)00326-3. PMID 7903.
- ^ Henn BM, Gignoux CR, Feldman MW, Mountain JL (January 2009). "Characterizing the time dependency of human mitochondrial DNA mutation rate estimates". Molecular Biology and Evolution. 26 (1): 217–30. doi:10.1093/molbev/msn244. PMID 18984905.
- ^ Ho SY, Phillips MJ, Cooper A, Drummond AJ (July 2005). "Time dependency of molecular rate estimates and systematic overestimation of recent divergence times". Molecular Biology and Evolution. 22 (7): 1561–8. doi:10.1093/molbev/msi145. PMID 15814826.
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