Aurein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Antimicrobial20
Antimicrobial20
Identifiers
Symbol	Antimicrobial20
Pfam	PF08256
InterPro	IPR013157
TCDB	1.C.76
OPM superfamily	211
OPM protein	1vm5
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

This family of antibacterial peptides are secreted from the granular dorsal glands of Litoria aurea (Green and golden bell frog), Litoria raniformis (Southern bell frog), Litoria citropa (Australian blue mountains tree frog) and frogs from genus Uperoleia. Amongst the more active of these are aurein 1.2,^[1] aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6;^[2] citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides.^[3]^[4]

References

^ "Differential Stability of Aurein 1.2 Pores in Model Membranes of Two Probiotic Strains". dx.doi.org. Retrieved 2023-10-03.
^ Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ (September 2000). "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 >". Eur. J. Biochem. 267 (17): 5330–41. doi:10.1046/j.1432-1327.2000.01536.x. PMID 10951191.
^ Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ (October 1999). "Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1". Eur. J. Biochem. 265 (2): 627–37. doi:10.1046/j.1432-1327.1999.00750.x. PMID 10504394.
^ Shahmiri, Mahdi; Enciso, Marta; Mechler, Adam (17 November 2015). "Controls and constrains of the membrane disrupting action of Aurein 1.2". Scientific Reports. 5 (1): 16378. Bibcode:2015NatSR...516378S. doi:10.1038/srep16378. PMC 4648102. PMID 26574052.

This article incorporates text from the public domain Pfam and InterPro: IPR013157

[1] "Differential Stability of Aurein 1.2 Pores in Model Membranes of Two Probiotic Strains". dx.doi.org. Retrieved 2023-10-03.

[pmid10951191-2] Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ (September 2000). "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 >". Eur. J. Biochem. 267 (17): 5330–41. doi:10.1046/j.1432-1327.2000.01536.x. PMID 10951191.

[pmid10504394-3] Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ (October 1999). "Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1". Eur. J. Biochem. 265 (2): 627–37. doi:10.1046/j.1432-1327.1999.00750.x. PMID 10504394.

[4] Shahmiri, Mahdi; Enciso, Marta; Mechler, Adam (17 November 2015). "Controls and constrains of the membrane disrupting action of Aurein 1.2". Scientific Reports. 5 (1): 16378. Bibcode:2015NatSR...516378S. doi:10.1038/srep16378. PMC 4648102. PMID 26574052.

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