Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre (Gurmar). It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats.[2]
As a sweet-taste-suppressing protein, gurmarin is only active on rodent sweet taste receptors but not on that of humans. ref: Appl Microbiol Biotechnol. 2012 Nov;96(3):619-30
References
^Arai K, Ishima R, Morikawa S, et al. (April 1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID7787425.
^Arai K, Aimoto S, Morikawa S, Yoshimura S, Ishima R, Imoto T, Miyasaka A, Akasaka K (1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID7787425.
