Parts of this article (those related to PMID17658730 and PMID18425604) need to be updated. Please help update this article to reflect recent events or newly available information.(November 2010)
The outer and inner segments of vertebrate retina rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the guanosine triphosphate-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A.[1] The protein is thought to participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the function of the protein is the same in both retina and pineal gland.[2]
^Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF (1990). "Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells". J. Biol. Chem. 265 (26): 15867–15873. PMID2203790.
