Yuan Chang

Yuan Chang
Yuan Chang
Born	November 17, 1959 (age 64); Taipei, Taiwan
Nationality	United States
Alma mater	University of Utah
Known for	Discovery of the human cancer viruses KSHV and MCV
Spouse	Patrick S. Moore
Awards	Meyenburg Prize (1997); Robert Koch Prize (1998); Charles S. Mott Prize (2003); Paul Marks Prize (2003); American Cancer Society Professorship ; Clarivate Citation Laureates (2017)
	Scientific career
Fields	Cancer, Virology, Pathology
Institutions	University of Pittsburgh Cancer Institute

Yuan Chang (simplified Chinese: 张远; traditional Chinese: 張遠; pinyin: Zhāng Yuǎn; born 17 November 1959) is an American virologist and pathologist who co-discovered Kaposi's sarcoma-associated herpesvirus (KSHV) and Merkel cell polyomavirus, two of the seven known human oncoviruses.

Early life and education

Chang was born in Taiwan and moved to the United States as a young child. She was raised in Salt Lake City, Utah and received an MD from the University of Utah College of Medicine. Chang trained in neuropathology at Stanford University under the noted clinical neuropathologist, Dikran Horoupian, publishing studies on eosinophilia-myalgia syndrome and progressive multifocal leukoencephalopathy. During this period she contributed to studies led by her friend, Julie Parsonnet, showing that Helicobacter pylori is a cause for gastric cancer.

Career

Chang moved to Columbia University to pursue her first academic appointment as a clinician-scientist. Although initially interested in using representational difference analysis to study the genetic origins of brain tumors, she applied this technique to Kaposi's sarcoma resulting in the discovery of this new human tumor virus. In 1994, she co-discovered KSHV,^[1] also called human herpesvirus-8 (HHV-8), working with her husband Patrick S. Moore at Columbia University. Chang, Moore and collaborators subsequently showed that this virus was the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma, while others showed it to be the cause of some forms of multicentric Castleman's disease. From two small DNA fragments representing less than 1% of the viral genome, she cloned the entire KSHV 165 kbase genome and fully sequenced the virus genome within two years after its initial discovery.^[2] This led to blood tests to detect infection for this virus, discovery of viral proteins likely to cause cancer and elucidation of the role of immune evasion in carcinogenesis caused by virus infection.^[3]

Dr. Chang is now the American Cancer Society Professor in the Department of Pathology at the University of Pittsburgh. She has received a number of awards for her work, including the Meyenburg Foundation Award for Cancer Research, the Robert Koch Prize, The Sloan-Kettering Paul Marks Prize for Cancer Research,^[4] the New York City Mayor's Award for Excellence in Science & Technology, the General Motors Charles S. Mott Prize in Cancer Research, the Carnegie Science Award and an American Cancer Society Research Professorship.

Selected works

Chang, Y; Cesarman, E; Pessin, M; et al. (1994). "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma". Science. 266 (5192): 1865–9. doi:10.1126/science.7997879. PMID 7997879.
Moore, PS; Chang, Y (1995). "Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection". N Engl J Med. 332 (18): 1181–5. doi:10.1056/nejm199505043321801. PMID 7700310.
Cesarman, E; Chang, Y; Moore, PS; Said, JW; Knowles, DM (1995). "Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas". N Engl J Med. 332 (18): 1186–91. doi:10.1056/nejm199505043321802. PMID 7700311.
Antman, K; Chang, Y (2000). "Kaposi's sarcoma". N Engl J Med. 342 (14): 1027–38. doi:10.1056/nejm200004063421407. PMID 10749966.

References

^ THE DOCTOR'S WORLD; Going Off the Beaten Path to Track Down Clues About AIDS
^ Russo, J. J.; Bohenzky, R. A.; Chien, M. C.; Chen, J.; Yan, M.; Maddalena, D.; Parry, J. P.; Peruzzi, D.; Edelman, I. S. (1996-12-10). "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14862–14867. doi:10.1073/pnas.93.25.14862. ISSN 0027-8424. PMC 26227. PMID 8962146.
^ Moore, Patrick S.; Chang, and Yuan (2003). "Kaposi's Sarcoma–Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?". Annual Review of Microbiology. 57 (1): 609–639. doi:10.1146/annurev.micro.57.030502.090824. PMC 3732455. PMID 14527293.
^ "Paul Marks Prize for Cancer Research | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 2017-10-02.

[1] THE DOCTOR'S WORLD; Going Off the Beaten Path to Track Down Clues About AIDS

[2] Russo, J. J.; Bohenzky, R. A.; Chien, M. C.; Chen, J.; Yan, M.; Maddalena, D.; Parry, J. P.; Peruzzi, D.; Edelman, I. S. (1996-12-10). "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14862–14867. doi:10.1073/pnas.93.25.14862. ISSN 0027-8424. PMC 26227. PMID 8962146.

[3] Moore, Patrick S.; Chang, and Yuan (2003). "Kaposi's Sarcoma–Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?". Annual Review of Microbiology. 57 (1): 609–639. doi:10.1146/annurev.micro.57.030502.090824. PMC 3732455. PMID 14527293.

[4] "Paul Marks Prize for Cancer Research | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 2017-10-02.

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