FCRL3

FCRL3
Identifiers
Aliases	FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs	OMIM: 606510; HomoloGene: 76447; GeneCards: FCRL3; OMA:FCRL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,700,769 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; granulocyte; ; lymph node; ; spleen; ; appendix; ; testicle; ; blood; ; epithelium of nasopharynx; ; tonsil; ; bone marrow cells;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase binding; phosphatase binding; protein phosphatase binding; protein tyrosine kinase binding;
Cellular component	membrane; integral component of membrane; plasma membrane; cell surface;
Biological process	negative regulation of immunoglobulin production; positive regulation of B cell proliferation; regulation of toll-like receptor 9 signaling pathway; positive regulation of MAPK cascade; regulation of B cell differentiation; negative regulation of B cell receptor signaling pathway; regulation of B cell activation; regulation of calcium ion import; positive regulation of protein serine/threonine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	115352
	n/a
	ENSG00000160856
	n/a
	Q96P31
	n/a
	NM_001024667; NM_052939; NM_001320333
	n/a
	NP_001307262; NP_443171
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.^[3]^[4]^[5]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.^[5]

Interactions

FCRL3 has been shown to interact with PTPN6.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
^ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). Fc receptor homologs (FcRH1-5) extend the Fc receptor family. Current Topics in Microbiology and Immunology. Vol. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205. {{cite book}}: |journal= ignored (help)
^ ^a ^b "Entrez Gene: FCRL3 Fc receptor-like 3".
^ Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Miller I; Hatzivassiliou G; Cattoretti G; et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kochi Y; Yamada R; Suzuki A; et al. (2005). "A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMC 1362949. PMID 15838509. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Simmonds MJ; Heward JM; Carr-Smith J; et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Eyre S; Bowes J; Potter C; et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Research & Therapy. 8 (4): R117. doi:10.1186/ar2006. PMC 1779391. PMID 16859508. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Umemura T; Ota M; Yoshizawa K; et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. hdl:10091/390. PMID 17020818. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Schäfer N; Blaumeiser B; Becker T; et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Newman WG; Zhang Q; Liu X; et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Choi CB; Kang CP; Seong SS; et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Owen CJ; Kelly H; Eden JA; et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
Martínez A; Núñez C; Martín MC; et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens. 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Martínez A; Mas A; de Las Heras V; et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160856 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11493702-3] Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.

[pmid12014205-4] Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). Fc receptor homologs (FcRH1-5) extend the Fc receptor family. Current Topics in Microbiology and Immunology. Vol. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205. {{cite book}}: |journal= ignored (help)

[entrez-5] "Entrez Gene: FCRL3 Fc receptor-like 3".

[pmid12051764-6] Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

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[3]

[4]

[5]

[6]

Interactions

References

Further reading