FAAH2

FAAH2
Identifiers
Aliases	FAAH2, AMDD, fatty acid amide hydrolase 2
External IDs	OMIM: 300654; HomoloGene: 45263; GeneCards: FAAH2; OMA:FAAH2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	57,489,193 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; pituitary gland; ; anterior pituitary; ; islet of Langerhans; ; skin of abdomen; ; skin of leg; ; minor salivary glands;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; fatty acid amide hydrolase activity;
Cellular component	integral component of membrane; lipid droplet; membrane;
Biological process	arachidonic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	158584
	n/a
	ENSG00000165591
	n/a
	Q6GMR7
	n/a
	NM_174912; NM_001353840; NM_001353841
	n/a
	NP_777572; NP_001340769; NP_001340770
	n/a
	Wikidata
View/Edit Human

Fatty acid amide hydrolase 2 or FAAH2 (EC 3.5.1.99, oleamide hydrolase 2, anandamide amidohydrolase 2) is a member of the serine hydrolase family of enzymes.^[3]

Fatty acid amide hydrolase 2 degrades endocannabinoids and defects in this enzyme have been associated with neurologic and psychiatric disorders.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165591 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF (December 2006). "A second fatty acid amide hydrolase with variable distribution among placental mammals". The Journal of Biological Chemistry. 281 (48): 36569–78. doi:10.1074/jbc.M606646200. PMID 17015445.
^ Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, et al. (March 2015). "Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms". Orphanet Journal of Rare Diseases. 10: 38. doi:10.1186/s13023-015-0248-3. PMC 4423390. PMID 25885783.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165591 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17015445-3] Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF (December 2006). "A second fatty acid amide hydrolase with variable distribution among placental mammals". The Journal of Biological Chemistry. 281 (48): 36569–78. doi:10.1074/jbc.M606646200. PMID 17015445.

[pmid25885783-4] Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, et al. (March 2015). "Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms". Orphanet Journal of Rare Diseases. 10: 38. doi:10.1186/s13023-015-0248-3. PMC 4423390. PMID 25885783.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1]

[2]

[3]

[4]

See also

References