DEFB127

DEFB127
Identifiers
Aliases	DEFB127, C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27, defensin beta 127
External IDs	HomoloGene: 89142; GeneCards: DEFB127; OMA:DEFB127 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	159,163 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tail of epididymis; ; testicle; ; caput epididymis; ; mucosa of ileum; ; kidney; ; human kidney; ; skin of abdomen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell surface; cellular component;
Biological process	defense response; defense response to bacterium; innate immune response; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	140850
	n/a
	ENSG00000088782
	n/a
	Q9H1M4
	n/a
	NM_139074
	n/a
	NP_620713
	n/a
	Wikidata
View/Edit Human

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.^[3]^[4]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088782 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
^ ^a ^b "Entrez Gene: DEFB127 defensin, beta 127".

van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131–8. doi:10.1016/S0091-6749(99)70004-7. PMID 10588992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088782 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11854508-3] Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.

[entrez-4] "Entrez Gene: DEFB127 defensin, beta 127".

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[3]

[4]

References

Further reading