SR9011

SR9011
Identifiers
	IUPAC name 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide;
CAS Number	1379686-29-9;
PubChem CID	57394021;
ChemSpider	28487552;
UNII	VYI79FLZ6W;
ChEMBL	ChEMBL1961797;
CompTox Dashboard (EPA)	DTXSID601045516 ;
Chemical and physical data
Formula	C23H31ClN4O3S
Molar mass	479.04 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCNC(=O)N1CCC(CN(Cc2ccc(Cl)cc2)Cc3ccc(s3)[N+](=O)[O-])C1;
	InChI InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29); Key:PPUYOYQTTWJTIU-UHFFFAOYSA-N;

SR9011 is a research drug that was developed by Professor Thomas Burris of Scripps as an agonist of Rev-ErbAα with a half-maximum inhibitory concentration (IC₅₀) = 790 nM for Rev-Erbα and IC₅₀ = 560 nM for Rev-ErbAβ.^[1]

References

^ Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, et al. (March 2012). "Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists". Nature. 485 (7396): 62–8. Bibcode:2012Natur.485...62S. doi:10.1038/nature11030. PMC 3343186. PMID 22460951. {{cite journal}}: Unknown parameter |lay-url= ignored (help); Unknown parameter |laysource= ignored (help)

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[pmid22460951-1] Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, et al. (March 2012). "Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists". Nature. 485 (7396): 62–8. Bibcode:2012Natur.485...62S. doi:10.1038/nature11030. PMC 3343186. PMID 22460951. {{cite journal}}: Unknown parameter |lay-url= ignored (help); Unknown parameter |laysource= ignored (help)

[1]

See also

References