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3-(Trifluoromethyl)aniline

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3-(Trifluoromethyl)aniline
Names
IUPAC name
3-(trifluoromethyl)aniline
Other names
3-Aminobenzotrifluoride; m-ABTF; m-Trifluoromethylaniline, 3-(Trifluoromethyl)phenyl-1-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.002.404 Edit this at Wikidata
UNII
  • InChI=1S/C7H6F3N/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H,11H2 checkY
    Key: VIUDTWATMPPKEL-UHFFFAOYSA-N checkY
  • InChI=1/C7H6F3N/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H,11H2
    Key: VIUDTWATMPPKEL-UHFFFAOYAM
  • FC(F)(F)c1cc(N)ccc1
Properties
C7H6F3N
Molar mass 161.12 g/mol
Density 1.29 g/cm3
Melting point 5 to 6 °C (41 to 43 °F; 278 to 279 K)
Boiling point 187 to 188 °C (369 to 370 °F; 460 to 461 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

3-(Trifluoromethyl)aniline is a compound with the molecular formula CF3C6H4NH2. It is an aromatic amine.

Drugs

3-(Trifluoromethyl)aniline is used in the production of:

  1. the herbicide fluometuron.[1] It is synthesized from benzotrifluoride via nitration followed by reduction to meta-H2NC6H4CF3. 3-(Trifluoromethyl)aniline is then converted to the urea, fluometuron.
  2. Flufenamic acid
  3. Morniflumate
  4. Ufenamate
  5. Flubanilate
  6. Salfluverine
  7. Colfenamate

References

  1. ^ Siegemund, Günter "Aromatic Compounds with Fluorinated Side-Chains" in Ullmann's Encyclopedia of Industrial Chemistry 2005, Wiley-VCH. doi:10.1002/14356007.a11_349.