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Yimon Aye

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Associate professor
Yimon Aye
Yimon Aye in 2018
Born1980 (age 43–44)
CitizenshipUS-American
Known forElectrophile signaling
Nucleotide signaling pathways
Academic background
EducationChemistry
Alma materUniversity of Oxford
Harvard University
Massachusetts Institute of Technology
Doctoral advisorDavid A. Evans
Other advisorsJoAnne Stubbe
Academic work
DisciplineBiology
Sub-disciplineMolecular Biology
InstitutionsEPFL
Main interestsSynthetic Methodology
Chemical Biology
Biochemistry
Biophysics
Molecular Biology
Cell Biology
Websitehttps://leago.epfl.ch

Yimon Aye (born 1980 in Burma) is an American chemist and molecular biologist. Her research is focused on molecular pathways involved in stress signaling and genome maintenance. She is Associate Professor at EPFL (École Polytechnique Fédérale de Lausanne) and leads the Laboratory of Electrophiles and Genome Operation (LEAGO) at the Institute of Chemical Sciences and Engineering.[1][2]

Career

Aye spent her early life in Burma. Sponsored by the Cambridge Tutors College, she moved to the UK to attend high school. She completed her undergraduate studies in chemistry at the University of Oxford and obtained her Master's degree in 2004.[3] She joined Harvard University to study synthetic organic chemistry with David A. Evans, achieving her PhD in 2009.[4] She then moved to Massachusetts Institute of Technology as a Damon Runyon Cancer Research Foundation fellow to work with JoAnne Stubbe. There she performed research into the regulatory mechanisms of ribonucleotide reductase.[5] In 2012, she started as an assistant professor at Cornell University, where she began her work on redox-dependent cell signaling and genome maintenance pathways. During this time, she developed REX technologies, new methods to facilitate the study of unconventional electrophile-regulated stress signaling paradigms.[6][7] REX technologies were one of the first approaches to forge direct links between upstream protein alteration by a reactive molecule and downstream responses.[4]

In 2018, she was appointed as a Assistant Professor of chemistry at EPFL.[1] Since August 2018, she has been leading the Laboratory of Electrophiles And Genome Operation (LEAGO) of the Institute of Chemical Sciences and Engineering (ISIC) at EPFL.[8]

Research

The Aye laboratory investigates cellular communication processes, in particular electrophile signaling and nucleotide signaling pathways.[9][10][11] The laboratory employs targeted photocaged electrophiles (REX technologies) that allow triggering of protein-specific electrophile-mediated signaling and enable the profiling of electrophile-sensor proteins.[12] They are also searching for ways apply of their findings in drug discovery.[13] A further research area focuses on ribonucleotide reductase, an enzyme present in all DNA-based life and one of the oldest enzymes. In this domain, the Aye laboratory has already discovered novel roles of ribonucleotide reductase, and other enzymes functioning in novel signaling axes, regulated by ribonucleotide reductase.[14]

Distinctions

In 2020, Aye was awarded the Arthur C. Cope Scholars Award,[15] the Eli Lilly Award in Biological Chemistry by the American Chemical Society (ACS),[16] the Hermann Esterbauer Memorial Award,[17] as well as the European Federation for Medicinal Chemistry (EFMC) Award for Young Medicinal Chemist in Academia.[18][19] In 2017, she received the Pershing Square Sohn Prize for Young Investigators,[20][21] Office of Naval Research Young Investigator Award,[22] and Buck-Whitney Award from the ACS.[23] In 2016, Aye received the Sloan Research Fellowship Award from the Alfred P. Sloan Foundation,[24] the Rising Star Chemical Biologist Award from the International Chemical Biology Society (ICBS),[25] Rising Star Chemist Award from the Women Chemists Committee (WCC) of the ACS,[25] and Chemical Research in Toxicology Young Investigator Award from the ACS Division of Chemical Toxicology.[26] In 2014, she received the National Institutes of Health (NIH) Director’s New Innovator Award,[27] National Science Foundation (NSF) CAREER Award,[28] and Beckman Young Investigator Award from the Arnold and Mabel Beckman Foundation.[29][30]

She is a member of the Swiss National Science Foundation’s NCCR Chemical Biology Steering Committee.[31]

Selected publications

References

  1. ^ a b "15 new professors appointed at the two Federal Institutes of Technology | ETH-Board". www.ethrat.ch. Retrieved 2020-09-21.
  2. ^ "Prof Yimon AYE". www.epfl.ch. Retrieved 2020-09-21.
  3. ^ admin (2018-01-12). "Interview with Dr.Yimon Aye Assistant Professor of Cornell University". Myanmar Insider. Retrieved 2020-09-21.
  4. ^ a b "2017 WCC Rising Star Dr. Yimon Aye – Corn... | ACS Network". communities.acs.org. Retrieved 2020-09-21.
  5. ^ "JoAnne Stubbe Research Group - MIT". web.mit.edu. Retrieved 2020-09-21.
  6. ^ Poganik, Jesse R.; Long, Marcus J. C.; Aye, Yimon (2019-02-11). "Interrogating Precision Electrophile Signaling". Trends in Biochemical Sciences. 44 (4): 380–381. doi:10.1016/j.tibs.2019.01.006. ISSN 0968-0004. PMC 6462755. PMID 30765181.
  7. ^ Long, Marcus J.C.; Urul, Daniel A.; Aye, Yimon (2020), "REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins", Methods in Enzymology, 633, Elsevier: 203–230, doi:10.1016/bs.mie.2019.02.039, ISBN 978-0-12-819128-6, PMC 7027669, PMID 32046846, retrieved 2020-09-21
  8. ^ "Laboratory of electrophiles and genome operation". www.epfl.ch. Retrieved 2020-09-21.
  9. ^ Long, Marcus J. C.; Zhao, Yi; Aye, Yimon (2020-01-16). "Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis". Cell Chemical Biology. 27 (1): 122–133.e5. doi:10.1016/j.chembiol.2019.11.012. ISSN 2451-9456. PMC 6980387. PMID 31836351.
  10. ^ Long, Marcus J.C.; Van Hall-Beauvais, Alexandra; Aye, Yimon (2019-11-15). "The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase". Current Opinion in Chemical Biology. 54: 10–18. doi:10.1016/j.cbpa.2019.09.003. PMC 7131891. PMID 31734537.
  11. ^ Long, Marcus J C; Parvez, Saba; Zhao, Yi; Surya, Sanjna L; Wang, Yiran; Zhang, Sheng; Aye, Yimon (2017-01-23). "Akt3 is a privileged first responder in isozyme-specific electrophile response". Nature Chemical Biology. 13 (3): 333–338. doi:10.1038/nchembio.2284. ISSN 1552-4450. PMC 5586141. PMID 28114274.
  12. ^ Liu, Xuyu; Long, Marcus J. C.; Hopkins, Benjamin D.; Luo, Chaosheng; Wang, Lingxi; Aye, Yimon (2020-06-24). "Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing". ACS Central Science. 6 (6): 892–902. doi:10.1021/acscentsci.9b00893. ISSN 2374-7943. PMC 7318068. PMID 32607436.
  13. ^ Long, Marcus J. C.; Hnedzko, Dziyana; Kim, Bo Kyoung; Aye, Yimon (2019-05-02). "Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery". ChemBioChem. 20 (9): 1091–1104. doi:10.1002/cbic.201800716. ISSN 1439-4227. PMC 6499692. PMID 30589188.
  14. ^ Fu, Yuan; Long, Marcus J. C.; Wisitpitthaya, Somsinee; Inayat, Huma; Pierpont, Timothy M.; Elsaid, Islam M.; Bloom, Jordana C.; Ortega, Joaquin; Weiss, Robert S.; Aye, Yimon (2018-08-27). "Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3". Nature Chemical Biology. 14 (10): 943–954. doi:10.1038/s41589-018-0113-5. ISSN 1552-4469. PMC 6171530. PMID 30150681.
  15. ^ "ACS 2021 national award winners". Chemical & Engineering News. Retrieved 2020-09-21.
  16. ^ "Eli Lilly Award in Biol ogi cal Chemistry" (PDF). Retrieved 2020-09-21.
  17. ^ "Hermann Esterbauer Award 2020". HNE-Club. Retrieved 2020-09-21.
  18. ^ "EFMC News in Medicinal Chemistry". www.efmc.info. Retrieved 2020-09-21.
  19. ^ Laetitia Petit. "I am a Medicinal Chemist/Chemical Biologist". www.efmc.info. Retrieved 2020-10-22.
  20. ^ "2017 Winners". Pershing Square Foundation. Retrieved 2020-09-21.
  21. ^ "ေဆးနဲ႔ ဓါတုသိပၸံထူးခြ်န္ဆုရ ျမန္မာအမ်ဳိးသမီး Dr. ရည္မြန္ေအး". ဗီြအိုေအ (in Burmese). Retrieved 2020-10-22.
  22. ^ "Aye, Shepherd win Young Investigator awards from Navy". Cornell Chronicle. Retrieved 2020-10-19.
  23. ^ "Chemistry professor honored with prestigious ACS award". as.cornell.edu. Retrieved 2020-10-19.
  24. ^ Good, Eleanor (2016-02-25). "Two Cornell Assistant Professors Named Sloan Research Fellows". The Cornell Daily Sun. Retrieved 2020-10-19.
  25. ^ a b "Yimon Aye Honored with Two Rising Star Awards | Chemistry & Chemical Biology Cornell Arts & Sciences". chemistry.cornell.edu. Retrieved 2020-10-19.
  26. ^ "Yimon Aye wins ACS award | Chemistry & Chemical Biology Cornell Arts & Sciences". chemistry.cornell.edu. Retrieved 2020-10-19.
  27. ^ "Yimon Aye named an NIH director's 'new innovator'". Cornell Chronicle. Retrieved 2020-10-19.
  28. ^ "NSF Award Search: Award#1351400 - CAREER: A Chemical Technology to Define Target-Specific Bioreactivity: Integrating Research and Education at the Crossroads of Chemistry and Biology". www.nsf.gov. Retrieved 2020-10-19.
  29. ^ "Yimon Aye is a Beckman Young Investigator". Cornell Chronicle. Retrieved 2020-10-19.
  30. ^ "Yimon Aye". Arnold and Mabel Beckman Foundation. Retrieved 2020-10-19.
  31. ^ "Steering Committee". NCCR in Chemical Biology. Retrieved 2020-09-21.
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