Isometamidium chloride

Isometamidium chloride
Clinical data
ATCvet code	QP51AX19 (WHO) ;
Identifiers
	IUPAC name 3-[N'-[(3-amino-5-ethyl-6-phenyl-8-phenanthridin-5-iumyl)imino]hydrazino]benzamidine chloride;
CAS Number	34301-55-8;
PubChem CID	92295;
ChemSpider	83326;
UNII	7NH28I651F;
CompTox Dashboard (EPA)	DTXSID10955855 ;
ECHA InfoCard	100.047.191
Chemical and physical data
Formula	C28H26ClN7
Molar mass	496.02 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Cl-].[N@H]=C(N)c1cc(ccc1)N/N=N/c4ccc3c2ccc(N)cc2[n+](c(c3c4)c5ccccc5)CC;
	InChI InChI=1S/C28H25N7.ClH/c1-2-35-26-16-20(29)11-13-24(26)23-14-12-22(17-25(23)27(35)18-7-4-3-5-8-18)33-34-32-21-10-6-9-19(15-21)28(30)31;/h3-17,29H,2H2,1H3,(H4,30,31,32,33);1H; Key:QNZJTSGALAVCLH-UHFFFAOYSA-N;

Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine.^[1]^[2]

It consists of a single Ethidium bromide like subunit linked to a fragment of the diminazene molecule.

References

^ Whitelaw DD, Bell IR, Holmes PH, Moloo SK, Hirumi H, Urquhart GM, Murray M (June 1986). "Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle". The Veterinary Record. 118 (26): 722–6. doi:10.1136/vr.118.26.722. PMID 3739193.
^ Peregrine AS, Ogunyemi O, Whitelaw DD, Holmes PH, Moloo SK, Hirumi H, Urquhart GM, Murray M (April 1988). "Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense". Veterinary Parasitology. 28 (1–2): 53–64. doi:10.1016/0304-4017(88)90018-0. PMID 3388736.

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