Actino-pnp RNA motif

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Actino-pnp RNA
Consensus secondary structure of Actino-pnp RNAs
Symbol Actino-pnp
Rfam RF01688
Other data
Domain(s) Bacteria
SO 0005836

The Actino-pnp RNA motif is a conserved structure found in actinobacteria that is apparently in the 5' untranslated regions of genes predicted to encode exoribonucleases.[1] The RNA element's function is likely analogous to an RNA structure found upstream of polynucleotide phosphorylase genes in E. coli and related enterobacteria.[2] In this latter system, the polynucleotide phosphorlyase gene regulates its own expression levels by a feedback mechanism that involves its activity upon the RNA structure. However, the E. coli RNA appears to be structurally unrelated to the Actino-pnp motif.


  1. ^ Weinberg, Zasha; Wang, Joy X.; Bogue, Jarrod; Yang, Jingying; Corbino, Keith; Moy, Ryan H.; Breaker, Ronald R. (2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes". Genome Biology. 11 (3): R31. PMC 2864571Freely accessible. PMID 20230605. doi:10.1186/gb-2010-11-3-r31. 
  2. ^ Jarrige, Anne-Charlotte; Mathy, Nathalie; Portier, Claude (2001). "PNPase autocontrols its expression by degrading a double-stranded structure in the pnp mRNA leader". The EMBO Journal. 20 (23): 6845–6855. PMC 125756Freely accessible. PMID 11726520. doi:10.1093/emboj/20.23.6845. 

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