Advantame
![]() | |
Names | |
---|---|
IUPAC name
(3S)-3-[3-(3-Hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
| |
Systematic IUPAC name
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester | |
Identifiers | |
| |
3D model (JSmol)
|
|
ChemSpider | |
E number | E969 (glazing agents, ...) |
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C24H30N2O7 | |
Molar mass | 458.511 g·mol−1 |
Appearance | white to yellow powder |
Melting point | 99.3–101.5 °C (210.7–214.7 °F; 372.4–374.6 K) |
Slightly soluble | |
Hazards | |
Safety data sheet (SDS) | External MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Advantame is a non-caloric sweetener from Japan's Ajinomoto Co.[1] The U.S. Food and Drug Administration has approved advantame for general use in foods and beverages except meat and poultry as a food additive. It is synthesized from isovanillin and aspartame.[2]
Advantame is classified as generally recognized as safe (GRAS) by the Flavor and Extract Manufacturers Association for use in dairy, frozen desserts, beverages, and chewing gum (FEMA #: 4716).[3] The Center for Science in the Public Interest ranks advantame as safe, together with neotame from other artificial intensity sweeteners.[4]
Animal studies have found no evidence for carcinogenicity or developmental toxicity.[5]
It is marketed as 20,000 times sweeter than sugar,[6] but it is not commonly used.[7]
References
- ^ "FDA Approves New No-Calorie Sweetener". Medscape. May 21, 2014. Retrieved 22 May 2014.
- ^ http://www.efsa.europa.eu/en/topics/topic/sweeteners
- ^ "Ajinomoto - Advantame Home". Advantame.
- ^ "Comparison and Safety Ratings of Food Additives". Center for Science in the Public Interest.
- ^ Otabe, A.; Fujieda, T.; Masuyama, T.; Ubukata, K.; Lee, C. (November 2011). "Advantame – An overview of the toxicity data". Food and Chemical Toxicology. 49: S2–S7. doi:10.1016/j.fct.2011.06.046.
- ^ "Food Additives & Ingredients - Additional Information about High-Intensity Sweeteners Permitted for Use in Food in the United States". Retrieved 14 January 2018.
- ^ "Nonnutritive Sweeteners: Current Use and Health Perspectives". Circulation. Retrieved 14 January 2018.
External links
Media related to Advantame at Wikimedia Commons