Lactate inflection point (LIP), is the exercise intensity at which the blood concentration of lactate and/or lactic acid begins to increase exponentially. It is often expressed as 85% of maximum heart rate or 75% of maximum oxygen intake. When exercising at or below the lactate threshold, any lactate produced by the muscles is removed by the body without it building up.
The onset of blood lactate accumulation (OBLA) is often confused with the lactate threshold. With a higher exercise intensity the lactate production exceeds at a rate which it cannot be broken down, the blood lactate concentration will show an increase equal to 4.0mM; it then accumulates at the muscle and then moves to the bloodstream.
Regular endurance exercise leads to adaptations in skeletal muscle which prevent lactate levels from rising. This is mediated via activation of PGC-1α which alters the isoenzyme composition of the LDH complex and decreases the activity of the lactate generating enzyme LDHA, while increasing the activity of the lactate metabolizing enzyme LDHB.
The lactate threshold is a useful measure for deciding exercise intensity for training and racing in endurance sports (e.g., long distance running, cycling, rowing, long distance swimming and cross country skiing), but varies between individuals and can be increased with training.
Interval training uses different work and rest periods allowing the body to temporarily exceed the lactate threshold at a high intensity, and then recover (reduce blood-lactate). This type of training uses the ATP-PC and the lactic acid system while exercising, which provides the most energy when there are short bursts of high intensity exercise followed by a recovery period. Interval training can take the form of many different types of exercise and should closely replicate the movements found in the sport being trained for. Interval training can be adjusted to the individual, however it is important to consider the intensity of each interval, duration or distance of each interval, length of rest/recovery, number of repetitions, frequency of training and recovery type.
Fartlek and interval training are similar, the main difference being the structure of the exercise. Fartlek is a Swedish word, meaning speed play. This type of training is a combination of continuous (generally aerobic) and interval training (generally anaerobic), involving consistent changes of pace/intensity throughout the session.
Aerobic and Anaerobic training
It is important to understand the difference between lactate threshold and lactic acid. Aerobic training will not help with lactic acid tolerance, however, it will increase the lactate threshold. The body will build a better tolerance to the effects of lactic acid over time during training. Anaerobic training improves the muscles’ alkaline reserves, allowing the muscles’ ability to work in the presence of increased lactic acid. Training at or slightly above the intensity where this occurs improves the lactate threshold.
Measuring lactate threshold
Muscles are producing lactate even at rest, usually about 0.8-1.5 mmol/L. Although the lactate threshold is defined as the point when lactic acid starts to accumulate, some testers approximate this by crossing the lactate threshold and using the point at which lactate reaches a concentration of 4 mmol/L of lactate. Accurately measuring the lactate blood concentration involves taking blood samples (normally a pinprick to the finger, earlobe or thumb) during a ramp test where the exercise intensity is progressively increased.
Accuracy of blood samples
Blood samples are a popular way of measuring the lactate blood concentration, however there are many factors that may affect the sample. Every individual has a different health status, thus the results from the blood lactate response can vary from factors prior to exercise such as the glycogen status of the participant and ambient temperature. “Furthermore, the lactate concentration measured may vary depending on the sampling site sweat contamination, and the accuracy of the lactate analyser.”  There are many factors that may give this test a false reading; it is important that an individual takes these into consideration, to receive an accurate test.
Lactate measurement of aerobic and anaerobic thresholds
The aerobic threshold (AeT or AerT) is sometimes defined as the exercise intensity at which blood lactate concentrations rise above resting levels. Anaerobic threshold (AnT) is sometimes defined equivalently to the lactate threshold(LT); as the exercise intensity beyond which blood lactate concentration is no longer linearly related to exercise intensity, but increases with both exercise intensity and duration. The blood lactate concentration at the anaerobic threshold is called the "maximum steady-state lactate concentration" (MLSS).
AeT is the exercise intensity at which anaerobic energy pathways start to operate, considered to be around 65-85% of an individual's maximum heart rate. Some have suggested this is where blood lactate reaches a concentration of 2 mmol/litre (at rest it is around 1). The anaerobic energy system increases the ability to produce blood lactate during maximal exercise, resulting from an increased amount of glycogen stores and glycolytic enzymes.
- Matthew L. Goodwin, M.A., James E. Harris, M.Ed., Andrés Hernández, M.A., and L. Bruce Gladden, Ph.D. (Jul 2007). "BlLactate Measurements and Analysis during Exercise: A Guide for Clinicians". J Diabetes Sci Technol. 1 (4): 558–569. doi:10.1177/193229680700100414. PMC 2769631. PMID 19885119.CS1 maint: multiple names: authors list (link)
- McPartland, Darren; Pree, Adrian; Malpeli, Robert; Telford, Amanda (2010). Nelson Physical Education Studies For WA. Australia: Nelson. ISBN 9780170182027.
- Faude, O; Kindermann, W; Meyer, T (2009). "Lactate threshold concepts; how valid are they?". Sports Medicine. 39 (6): 469–490. doi:10.2165/00007256-200939060-00003.
- Summermatter, Serge; Santos, Gesa; Pérez-Schindler, Joaquín; Handschin, Christoph (2013-05-21). "Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 110 (21): 8738–8743. doi:10.1073/pnas.1212976110. ISSN 1091-6490. PMC 3666691. PMID 23650363.
- Hood, M. S; Little, J. P; Tarnopolsky, M. A; Myslik, F; Gibala, M. J (2011). "Low volume interval training improve muscle oxidative capacity in sedentary adults". Medicine and Science in Sports and Exercise. 43 (10): 1849–1856. doi:10.1249/MSS.0b013e3182199834. PMID 21448086.
- LaBossiere, Cris (2007). "Blood lactate testing: what is it, how is it done?". Rhino Fitness.
- Moran, P, Prichard, JG, Ansley, L, and Howatson, G (Feb 2012). "The influence of blood lactate sample site on exercise prescription". J Strength Cond Res. 26 (2): 563–567. doi:10.1519/JSC.0b013e318225f395. PMID 22240552.CS1 maint: multiple names: authors list (link)
- Mann T, Lamberts RP, Lambert MI (Jul 2013). "Methods of prescribing relative exercise intensity: physiological and practical considerations". Sports Med. 43 (7): 613–625. doi:10.1007/s40279-013-0045-x. PMID 23620244.